TCF7L2 多态性与中国人群 2 型糖尿病风险的关联的荟萃分析。
Meta-analysis of associations between TCF7L2 polymorphisms and risk of type 2 diabetes mellitus in the Chinese population.
机构信息
Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou, 450000, People's Republic of China.
出版信息
BMC Med Genet. 2013 Jan 12;14:8. doi: 10.1186/1471-2350-14-8.
BACKGROUND
Associations between transcription factor 7-like 2 (TCF7L2) polymorphisms and type 2 diabetes mellitus (T2DM) have been evaluated extensively in multiple ethnic groups. TCF7L2 has emerged as the strongest T2DM susceptibility gene in Europeans, but the findings have been inconsistent in the Chinese population. The purpose of this meta-analysis was to evaluate the associations between TCF7L2 single nucleotide polymorphisms (SNPs) and T2DM risk in the Chinese population.
METHODS
We performed searches in the PubMed, EMBASE, Cochrane, and Chinese databases (CNKI, CQVIP and Wanfang databases) for literature published from January 2007 to February 2012. We reviewed all relevant articles on TCF7L2 polymorphisms and susceptibility to T2DM in the Chinese population written in English and Chinese. Two reviewers extracted data independently using a standardized protocol, and any discrepancies were adjudicated by a third reviewer. Fixed-effects and random-effects meta-analyses were performed to pool the odds ratios (ORs). Publication bias and heterogeneity were examined.
RESULTS
A total of 21 articles were confirmed to be eligible for and included in this meta-analysis: 7 (with 3942 cases and 3502 controls) concerning rs11196218 (IVS-/+4G>A), 8 (with 3377 cases and 2975 controls) concerning rs290487 (IVS3-/+C>T), and 14 (with 7902 cases and 7436 controls) concerning rs7903146 (IVS3-/+C>T). Overall, the results showed a significant association between rs7903146 and T2DM risk. The pooled ORs were 1.54 for the comparison of T and C alleles (95% CI [confidence interval]: 1.37-1.74, p = 1.47 × 10-12, I2 = 25.20%) and 1.56 for TC heterozygotes and CC homozygotes (95% CI : 1.38-1.76, p = 8.25 × 10-9, I2 = 21.00%). The rs11196218(IVS4G>A) and rs290487 (IVS3C>T) SNPs were not associated with T2DM risk.
CONCLUSIONS
The rs7903146 SNP of the TCF7L2 gene is associated with increased susceptibility to T2DM in the Chinese population as a whole as well as northern Chinese and southern Chinese as subgroups.
背景
转录因子 7 样 2（TCF7L2）多态性与 2 型糖尿病（T2DM）之间的关联已在多个种族中进行了广泛评估。TCF7L2 已成为欧洲人最强的 2 型糖尿病易感性基因，但在中国人群中的研究结果并不一致。本荟萃分析的目的是评估 TCF7L2 单核苷酸多态性（SNPs）与中国人群 2 型糖尿病风险之间的关系。
方法
我们检索了 2007 年 1 月至 2012 年 2 月发表的英文和中文文献，包括 PubMed、EMBASE、Cochrane 以及中国的数据库（CNKI、CQVIP 和万方数据库）。我们回顾了所有关于 TCF7L2 多态性与中国人群 2 型糖尿病易感性的相关文章。两名评审员使用标准化协议独立提取数据，如果有任何分歧，由第三名评审员裁决。采用固定效应和随机效应荟萃分析来合并优势比（ORs）。评估了发表偏倚和异质性。
结果
共有 21 篇文章被确认为符合纳入标准并包括在本荟萃分析中：7 篇（3942 例病例和 3502 例对照）涉及 rs11196218（IVS-/+4G>A），8 篇（3377 例病例和 2975 例对照）涉及 rs290487（IVS3-/+C>T），14 篇（7902 例病例和 7436 例对照）涉及 rs7903146（IVS3-/+C>T）。总体而言，结果显示 rs7903146 与 T2DM 风险之间存在显著关联。T 和 C 等位基因比较的汇总 OR 为 1.54（95%置信区间：1.37-1.74，p = 1.47×10-12，I2 = 25.20%），TC 杂合子和 CC 纯合子的汇总 OR 为 1.56（95%置信区间：1.38-1.76，p = 8.25×10-9，I2 = 21.00%）。rs11196218（IVS4G>A）和 rs290487（IVS3C>T）SNP 与 T2DM 风险无关。
结论
TCF7L2 基因的 rs7903146 SNP 与中国人群 T2DM 的易感性增加有关，包括北方和南方汉族人群。
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