磷脂酰胆碱与CDP-胆碱循环。
Phosphatidylcholine and the CDP-choline cycle.
作者信息
Fagone Paolo, Jackowski Suzanne
机构信息
Department of Hematology, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
出版信息
Biochim Biophys Acta. 2013 Mar;1831(3):523-32. doi: 10.1016/j.bbalip.2012.09.009. Epub 2012 Sep 23.
Abstract
The CDP-choline pathway of phosphatidylcholine (PtdCho) biosynthesis was first described more than 50 years ago. Investigation of the CDP-choline pathway in yeast provides a basis for understanding the CDP-choline pathway in mammals. PtdCho is considered as an intermediate in a cycle of synthesis and degradation, and the activity of a CDP-choline cycle is linked to subcellular membrane lipid movement. The components of the mammalian CDP-choline pathway include choline transport, choline kinase, phosphocholine cytidylyltransferase, and choline phosphotransferase activities. The protein isoforms and biochemical mechanisms of regulation of the pathway enzymes are related to their cell- and tissue-specific functions. Regulated PtdCho turnover mediated by phospholipases or neuropathy target esterase participates in the mammalian CDP-choline cycle. Knockout mouse models define the biological functions of the CDP-choline cycle in mammalian cells and tissues. This article is part of a Special Issue entitled Phospholipids and Phospholipid Metabolism.
摘要
磷脂酰胆碱（PtdCho）生物合成的CDP-胆碱途径早在50多年前就首次被描述。对酵母中CDP-胆碱途径的研究为理解哺乳动物中的CDP-胆碱途径提供了基础。PtdCho被认为是合成与降解循环中的一个中间体，并且CDP-胆碱循环的活性与亚细胞膜脂质运动相关。哺乳动物CDP-胆碱途径的组成部分包括胆碱转运、胆碱激酶、磷酸胆碱胞苷转移酶和胆碱磷酸转移酶活性。该途径酶的蛋白质异构体和生化调节机制与其细胞和组织特异性功能相关。由磷脂酶或神经病变靶标酯酶介导的受调控的PtdCho周转参与哺乳动物CDP-胆碱循环。基因敲除小鼠模型确定了CDP-胆碱循环在哺乳动物细胞和组织中的生物学功能。本文是名为“磷脂与磷脂代谢”的特刊的一部分。
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