Institute of Liver Studies and Paediatric Liver, GI & Nutrition Centre, King's College Hospital, King's College London School of Medicine, London, UK.
Semin Immunopathol. 2013 Jan;35(1):73-85. doi: 10.1007/s00281-012-0328-6. Epub 2012 Jul 28.
Infections by the viruses responsible for hepatitis B, C and D are accompanied by a number of immunopathological manifestations. A link between infection and autoimmunity is particularly well documented for the hepatitis C virus. Immunopathological manifestations range from production of autoantibodies to overt autoimmune disease, including thyroiditis and autoimmune hepatitis, and to immune-complex-mediated disorders, including cryoglobulinaemia, glomerulonephritis and vasculitis. Several of these manifestations improve with successful antiviral treatment, directly incriminating the virus in their pathogenesis. Mechanisms considered responsible for hepatitis virus-related immunopathology, including molecular mimicry, impairment of regulatory T cells and activation of B lymphocytes, will be examined in this review.
由乙型、丙型和丁型肝炎病毒引起的感染伴随着许多免疫病理表现。丙型肝炎病毒尤其有充分的证据表明其感染与自身免疫之间存在关联。免疫病理表现范围从产生自身抗体到明显的自身免疫性疾病，包括甲状腺炎和自身免疫性肝炎，以及免疫复合物介导的疾病，包括冷球蛋白血症、肾小球肾炎和血管炎。其中一些表现随着抗病毒治疗的成功而改善，这直接证明了病毒在发病机制中的作用。在本综述中，我们将研究被认为与肝炎病毒相关免疫病理有关的机制，包括分子模拟、调节性 T 细胞功能障碍和 B 淋巴细胞激活。
