Bech P, Poulsen D L, Garre K, Rasmussen K, Jensen H E
Centralsygehuset i Hillerød, psykiatrisk afdeling.
Ugeskr Laeger. 1990 Feb 5;152(6):383-6.
The quality of life has become an important element in assessment of medicinal treatment. As an independent expression, the quality of life covers the human disappointments which a medical disease may involve ("discomfort") whereas the clinical dysfunction caused by the disease is covered by the expression "disability". In the treatment of essential arterial hypertension, the clinical symptoms of the disease are few or none ("asymptomatic hypertension"). In an investigation of 303 patients in general practice for arterial hypertension, the significance of the frequency of dosage of metoprolol (Seloken) was assessed by means of measurement of the quality of life by the General Health Questionnaire (GHQ), a questionnaire which contains components such as fatigue, sleep, anxiety and depression. No advantages in the quality of life were found in administering antihypertensive drugs once or twice daily. From the methological point of view, the following conditions were found which should be taken into consideration in future investigations in this field: The GHQ was found to be easy for the patients to employ. This is important as the quality of life is a personally experienced dimension. The questionnaire correlated adequately with the visual analogue scales. Approximately 1/3 of the patients had reduced quality of life at the commencement of the investigation as assessed by GHQ. A multiple regression analysis revealed that the reduced well-being was due to social, life events and side effects. It is therefore recommended that these aspects should be described when patients commence a course of medicinal treatment i.e. the social life events and side effects of the medicine in connection with the actual subjective dimension of quality of life.
生活质量已成为药物治疗评估中的一个重要因素。作为一种独立的表述，生活质量涵盖了医疗疾病可能涉及的人类失望情绪（“不适”），而疾病导致的临床功能障碍则用“残疾”这一表述来涵盖。在原发性高血压的治疗中，该疾病的临床症状很少或没有（“无症状性高血压”）。在一项对303例普通科高血压患者的调查中，通过一般健康问卷（GHQ）对生活质量进行测量，评估了美托洛尔（倍他乐克）的用药频率的意义，该问卷包含疲劳、睡眠、焦虑和抑郁等成分。每日服用一次或两次抗高血压药物在生活质量方面未发现优势。从方法学角度来看，发现了以下在该领域未来研究中应予以考虑的情况：发现GHQ对患者来说易于使用。这很重要，因为生活质量是一个个人体验的维度。该问卷与视觉模拟量表有充分的相关性。根据GHQ评估，约1/3的患者在调查开始时生活质量下降。多元回归分析显示，幸福感下降是由于社会、生活事件和副作用。因此，建议在患者开始药物治疗疗程时描述这些方面，即与生活质量的实际主观维度相关的社会生活事件和药物副作用。
