Department of Medicine, Sinai Hospital Program in Internal Medicine, Johns Hopkins University, 2401 W. Belvedere Ave, Baltimore, MD, 21215, USA,
Rheumatol Int. 2013 Oct;33(10):2671-3. doi: 10.1007/s00296-012-2467-4. Epub 2012 Aug 3.
AVN is caused by a disease, or severe trauma that affects the blood supply to the bone or in many cases may be idiopathic, with no known cause. AVN pathophysiology is most closely linked to SLE literature, and there is a strong cause and effect relationship between corticosteroid intake and AVN development in SLE patients, and AVN is extremely rare in the absence of steroid use. Apart from few anecdotal reports, there is no data on exact pathophysiologic mechanisms responsible for AVN in the setting of vasculitis. We saw a 69-year-old man with femoral AVN and a possibility of vasculitis as the underlying cause was raised by the radiologist, and hence we present this literature search on vasculitis per se causing AVN of the bone.
AVN 是由疾病或严重创伤引起的，这些疾病或创伤会影响骨骼的血液供应，在许多情况下，AVN 可能是特发性的，其病因尚不清楚。AVN 的病理生理学与 SLE 文献密切相关，SLE 患者中皮质类固醇的摄入与 AVN 的发展之间存在很强的因果关系，在没有使用类固醇的情况下，AVN 极为罕见。除了少数传闻病例外，在血管炎的情况下，关于导致 AVN 的确切病理生理机制的数据尚不清楚。我们观察到一名 69 岁男性患有股骨 AVN，放射科医生提出血管炎可能是潜在病因，因此我们就血管炎本身导致骨骼 AVN 进行了文献检索。
