系统性红斑狼疮患者骨缺血性坏死的危险因素：抗磷脂抗体起作用吗？
Risk factors for avascular necrosis of bone in patients with systemic lupus erythematosus: is there a role for antiphospholipid antibodies?
作者信息
Mok M Y, Farewell V T, Isenberg D A
机构信息
Bloomsbury Rheumatology Unit, University College London Medical School, Hong Kong.
出版信息
Ann Rheum Dis. 2000 Jun;59(6):462-7. doi: 10.1136/ard.59.6.462.
Abstract
BACKGROUND
Avascular necrosis of bone (AVN) is a well known complication in patients with systemic lupus erythematosus (SLE).
OBJECTIVE
To investigate the role of antiphospholipid antibody status (IgM and IgG anticardiolipin antibodies and lupus anticoagulant) with adjustment for corticosteroid use as risk factors for the development of AVN.
METHODS
A cohort of 265 patients receiving long term follow up in our SLE clinic from 1978 to 1998 was analysed. Patients with AVN complications were detected and then matched for age, sex, ethnicity, duration of disease, and organ disease with two other patients with SLE. A further 31 patients were chosen at random for the analysis.
RESULTS
Eleven patients had AVN, giving a point prevalence of 4%. There were no significant differences demonstrable in the presence of individual antiphospholipid antibodies (aPL) or their combination between the group with AVN or the two control groups.
CONCLUSION
Incorporating an adjustment for corticosteroid use we were unable to show a link between the presence of aPL and the development of AVN in patients with SLE.
摘要
背景
骨缺血性坏死（AVN）是系统性红斑狼疮（SLE）患者中一种众所周知的并发症。
目的
研究抗磷脂抗体状态（IgM和IgG抗心磷脂抗体及狼疮抗凝物）在调整皮质类固醇使用情况后作为AVN发生风险因素的作用。
方法
分析了1978年至1998年在我们的SLE诊所接受长期随访的265例患者队列。检测出有AVN并发症的患者，然后将其与另外两名SLE患者在年龄、性别、种族、病程和器官疾病方面进行匹配。另外随机选择31例患者进行分析。
结果
11例患者发生AVN，点患病率为4%。在有AVN的组与两个对照组之间，单个抗磷脂抗体（aPL）的存在或其组合均无明显差异。
结论
在调整皮质类固醇使用情况后，我们未能显示出SLE患者中aPL的存在与AVN发生之间的联系。
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