Amouzadeh H R, Sangiah S
Department of Physiological Sciences, College of Veterinary Medicine, Oklahoma State University, Stillwater 74078-0353.
Vet Hum Toxicol. 1990 Feb;32(1):19-22.
The effects of streptozotocin-induced diabetes and insulin on the duration of xylazine-ketamine anesthesia were studied in rats. The duration of anesthesia was significantly reduced in diabetic group as compared to control group. In contrast, the duration of anesthesia in insulin-treated non-diabetic group was not significantly different from control group. The plasma glucose level in control group was increased significantly during and upon recovery from anesthesia as compared to pre-anesthetic levels. The plasma glucose level in diabetic group was not changed during anesthesia; however, it was reduced significantly upon recovery. The plasma glucose level was significantly reduced in insulin-treated group as compared to pre-anesthetic levels. The reduction in duration of anesthesia in diabetic rats is possibly due to enhanced metabolism xylazine and/or ketamine and is independent of plasma glucose level.
研究了链脲佐菌素诱导的糖尿病和胰岛素对大鼠赛拉嗪-氯胺酮麻醉持续时间的影响。与对照组相比，糖尿病组的麻醉持续时间显著缩短。相比之下，胰岛素治疗的非糖尿病组的麻醉持续时间与对照组无显著差异。与麻醉前水平相比，对照组在麻醉期间及苏醒时血浆葡萄糖水平显著升高。糖尿病组在麻醉期间血浆葡萄糖水平未发生变化；然而，苏醒时显著降低。与麻醉前水平相比，胰岛素治疗组的血浆葡萄糖水平显著降低。糖尿病大鼠麻醉持续时间缩短可能是由于赛拉嗪和/或氯胺酮代谢增强，且与血浆葡萄糖水平无关。
