Mosha R D, Gyrd-Hansen N
Department of Pharmacology and Toxicology, Royal Veterinary and Agricultural University, Frederiksberg, Denmark.
Vet Hum Toxicol. 1990 Feb;32(1):6-8.
Cholinesterase activities were measured in plasma and in red blood cells from 6 goats after iv injection of the organophosphorus insecticide ethion at 3 different dose levels--2 mg/kg, 5 mg/kg and 10 mg/kg. Plasma levels of ethion after injection were established. At 2 mg/kg no signs of toxicity were observed and the blood cholinesterase activity remained above 65% of the control value. After administration of the higher doses the goats showed signs of severe toxicity corresponding to increased parasympathetic stimulation. Cholinesterase activities in blood were reduced to approximately 10% of the control value for the 5 mg/kg group and to approximately 5% for the 10 mg/kg group. Reactivation of cholinesterase activity in blood cells and plasma by means of pralidoxime was very efficient during the first 24 hr after administration of ethion, but was insignificant after 72 hours.
给6只山羊静脉注射三种不同剂量水平（2毫克/千克、5毫克/千克和10毫克/千克）的有机磷杀虫剂乙硫磷后，测定了血浆和红细胞中的胆碱酯酶活性。注射后测定了血浆中的乙硫磷水平。在2毫克/千克剂量时，未观察到毒性迹象，血液胆碱酯酶活性保持在对照值的65%以上。给予较高剂量后，山羊出现严重毒性迹象，对应副交感神经刺激增强。5毫克/千克组血液中的胆碱酯酶活性降至对照值的约10%，10毫克/千克组降至约5%。在给予乙硫磷后的头24小时内，用解磷定使血细胞和血浆中的胆碱酯酶活性重新激活非常有效，但72小时后效果不明显。
