Bahiana School of Medicine and Public Health, Salvador, Bahia, Brazil.
J Ultrasound Med. 2012 Oct;31(10):1659-64. doi: 10.7863/jum.2012.31.10.1659.
The purposes of this study were to describe ophthalmic artery Doppler parameters in pregnant women at risk for preeclampsia in the second trimester, compare them with reference values described in women with healthy pregnancies, and evaluate the association between gestational age and Doppler parameters.
We conducted an observational study with prospective data collection in which measurements of 7 ophthalmic artery Doppler parameters were obtained in 274 women at 20 to 28 weeks' gestation with clinical risk factors for preeclampsia. The following measurements were obtained: peak systolic velocity, mesodiastolic velocity, mean velocity, end-diastolic velocity, resistive index, pulsatility index, and peak ratio. The observed Doppler values were compared with reference values by a 1-sample t test. To test for linear associations between gestational age and Doppler parameters, the Pearson correlation coefficient was used.
Significantly higher ophthalmic artery Doppler velocimetric parameters were observed when compared with the reference values. The mean values of these parameters ± SD were as follows: peak systolic velocity, 37.9 ± 10.3 cm/s (reference, 34.2 cm/s; P < .001); end-diastolic velocity, 7.2 ± 3.1 cm/s (reference, 6.8 cm/s; P = .03); resistive index, 0.81 ± 0.07 (reference, 0.70; P < .001); pulsatility index, 2.17 ± 0.53 (reference, 1.80; P < .001); and peak ratio, 0.53 ± 0.12 (reference, 0.40; P < .001). There was no correlation between the Doppler parameters and gestational age.
Ophthalmic Doppler parameters of women at risk for preeclampsia are significantly higher than reference values for healthy pregnancies, which may indicate an inadequate vascular response to persistent peripheral resistance. Gestational age during the second trimester is not associated with ophthalmic artery Doppler parameters in pregnant women at risk for preeclampsia.
本研究旨在描述有子痫前期风险的孕妇在妊娠中期的眼动脉多普勒参数，将其与健康妊娠女性的参考值进行比较，并评估与多普勒参数相关的孕周。
我们进行了一项观察性研究，前瞻性收集 274 名妊娠 20 至 28 周且有子痫前期临床风险因素的孕妇的 7 项眼动脉多普勒参数测量值。测量的参数如下：收缩期峰值速度、舒张中期速度、平均速度、舒张末期速度、阻力指数、搏动指数和峰值比。采用单样本 t 检验比较观察到的多普勒值与参考值。为了测试孕周与多普勒参数之间的线性关系，使用 Pearson 相关系数。
与参考值相比，眼动脉多普勒血流速度参数明显升高。这些参数的平均值±标准差如下：收缩期峰值速度，37.9±10.3cm/s（参考值 34.2cm/s；P＜0.001）；舒张末期速度，7.2±3.1cm/s（参考值 6.8cm/s；P=0.03）；阻力指数，0.81±0.07（参考值 0.70；P＜0.001）；搏动指数，2.17±0.53（参考值 1.80；P＜0.001）；和峰值比，0.53±0.12（参考值 0.40；P＜0.001）。多普勒参数与孕周之间无相关性。
有子痫前期风险的孕妇的眼动脉多普勒参数明显高于健康妊娠的参考值，这可能表明血管对持续外周阻力的反应不足。妊娠中期的孕周与有子痫前期风险的孕妇的眼动脉多普勒参数无关。
