Paes Maria Marta B M, Diniz Angélica L D
a Department of Ultrasonography and.
b Department of Gynecology and Obstetrics , Federal University of Uberlândia , Uberlândia , Brazil.
J Matern Fetal Neonatal Med. 2015;28(17):2074-9. doi: 10.3109/14767058.2014.978756. Epub 2014 Nov 11.
Our aim was to investigate the hemodynamic profile of the ophthalmic artery in preeclamptic women, pregnant smokers and pregnant controls with no known diseases.
A prospective cross-sectional study using the performed ophthalmic artery Doppler ultrasonography in 20 mild preeclamptic women and 20 severe preeclamptic women, 37 pregnant smokers and 51 controls. Data evaluated by using Doppler ultrasonography were as follows: resistance index, pulsatility index, peak systolic velocity, end diastolic velocity, second peak systolic velocity and peak ratio. The Doppler results, gestational age, patient age and systolic and diastolic pressure of groups were subjected to analysis of variance (p < 0.05).
Both groups of preeclamptic women presented significant orbital hyperperfusion (resistance index: 0.64 ± 0.07 and 0.64 ± 0.13, pulsatility index:1.10 ± 0.26 and 1.02 ± 0.30, end diastolic velocity:14.13 ± 4.44 and 15.66 ± 4.17), whereas pregnant smokers showed vasospasm (0.84 ± 0.04, 2.27 ± 0.43, 4.78 ± 1.28, respectively) indicating divergent vascular pattern between these two groups (p < 0.01) and differences between each group and controls (0.78 ± 0.06, 1.89 ± 0.36, 7.43 ± 2.71), respectively, p < 0.01. Peak systolic velocity mean values for severe preeclamptic women was 40.36 ± 5.61 cm/s, significantly higher than in all groups (34.53 ± 6.82 cm/s, 31.03 ± 4.72 cm/s and 34.35 ± 6.43 cm/s).
Preeclamptic women have presented hyperperfusion whereas chronic smokers have shown hypoperfusion in ophthalmic artery. Thus, chronic flow changes in pregnant smokers might reduce the number of sudden and catastrophic events in preeclampsia.
我们的目的是研究先兆子痫女性、孕期吸烟女性和无已知疾病的孕期对照女性的眼动脉血流动力学特征。
一项前瞻性横断面研究，对20例轻度先兆子痫女性、20例重度先兆子痫女性、37例孕期吸烟女性和51例对照者进行眼动脉多普勒超声检查。通过多普勒超声评估的数据如下：阻力指数、搏动指数、收缩期峰值流速、舒张末期流速、第二收缩期峰值流速和峰值比。对各组的多普勒结果、孕周、患者年龄以及收缩压和舒张压进行方差分析（p < 0.05）。
两组先兆子痫女性均表现出明显的眼眶高灌注（阻力指数：0.64±0.07和0.64±0.13，搏动指数：1.10±0.26和1.02±0.30，舒张末期流速：14.13±4.44和15.66±4.17），而孕期吸烟女性表现出血管痉挛（分别为0.84±0.04、2.27±0.43、4.78±1.28），表明这两组之间血管模式不同（p < 0.01），且每组与对照组之间也存在差异（分别为0.78±0.06、1.89±0.36、7.43±2.71），p < 0.01。重度先兆子痫女性的收缩期峰值流速平均值为40.36±5.61 cm/s，显著高于所有其他组（34.53±6.82 cm/s、31.03±4.72 cm/s和34.35±6.43 cm/s）。
先兆子痫女性表现为高灌注，而孕期吸烟女性的眼动脉表现为低灌注。因此，孕期吸烟女性的慢性血流变化可能会减少先兆子痫中突发和灾难性事件的发生数量。
