Kanda Takeshi, Itoh Hiroshi
Health Center, School of Medicine, Keio University.
Nihon Rinsho. 2012 Sep;70(9):1487-91.
The renin-angiotensin-aldosterone system(RAAS) plays a crucial role in the regulation of physiological homeostasis and diseases such as hypertension, coronary artery disease and chronic renal failure. In this cascade, the ACE/Ang II/AT1 receptor axis induces pathological effects, such as vasoconstriction, cell proliferation and fibrosis. Recently the ACE2/Ang(1-7)/Mas receptor axis has been recognized as a negative regulator of the RAAS. ACE2 metabolizes Ang II into Ang(1-7), which has opposite properties of Ang II through Mas receptor activation. Both animal and human studies provide strong evidence that the ACE2/Ang(1-7)/Mas receptor axis is protective for end-organ damage. Therefore, the ACE2/Ang(1-7)/Mas receptor axis could be a therapeutic target for coronary artery disease and chronic renal failure.
肾素-血管紧张素-醛固酮系统（RAAS）在生理稳态调节以及高血压、冠状动脉疾病和慢性肾衰竭等疾病中发挥着关键作用。在这一连锁反应中，ACE/Ang II/AT1受体轴会引发诸如血管收缩、细胞增殖和纤维化等病理效应。最近，ACE2/Ang（1-7）/Mas受体轴已被确认为RAAS的负调节因子。ACE2将Ang II代谢为Ang（1-7），后者通过激活Mas受体具有与Ang II相反的特性。动物和人体研究均提供了强有力的证据表明，ACE2/Ang（1-7）/Mas受体轴对终末器官损伤具有保护作用。因此，ACE2/Ang（1-7）/Mas受体轴可能成为冠状动脉疾病和慢性肾衰竭的治疗靶点。
