Nunes-Silva Albena, Rocha Guilherme Carvalho, Magalhaes Daniel Massote, Vaz Lucas Neves, Salviano de Faria Marcelo Henrique, Simoes E Silva Ana Cristina
Sport Center of Federal University of Ouro Preto (CEDUFOP).
Interdisciplinary Laboratory of Medical Investigation, Faculty of Medicine, Federal University of Minas Gerais, MG, Brazil.
Protein Pept Lett. 2017 Nov 17;24(9):809-816. doi: 10.2174/0929866524666170728151401.
Many physiological responses of the Renin Angiotensin System (RAS) are associated with two opposite pathways: (1) a classical one formed by angiotensin-converting enzyme (ACE), Angiotensin II (Ang II) and Angiotensin type 1 (AT1) receptor, which is associated to vasoconstriction, cell proliferation, organ hypertrophy, sodium retention and aldosterone release and (2) a counter-regulatory or vasodilator pathway comprising angiotensin-converting enzyme 2 (ACE2), Angiotensin-(1-7) [Ang-(1-7)] and Mas receptor, which is involved in vasodilation, antiproliferation, anti-hypertrophy, cardioprotective and renoprotective actions.
This review aimed to bring up-to-date on the interactions between physical exercise and the vasodilator axis of the RAS (ACE2-Ang-(1-7)-Mas receptor axis). We also investigated the relation of acute and chronic exercise with blood pressure regulation and components of the vasodilator axis of the RAS.
We searched studies with animal models and humans in PUBMED, LILACS and IBECS.
Experimental studies showed that physical training can stimulate ACE2-Ang-(1-7)-Mas receptor axis in parallel with the inhibition of ACE-Ang II-AT1 receptor pathway. However, up to now, the interaction between the counter-regulatory RAS axis and physical training is not investigated in humans.
The activation of ACE2-Ang-(1-7)-Mas receptor axis may have a role in the beneficial effects of physical training in experimental models. Further studies with humans are necessary.
肾素-血管紧张素系统（RAS）的许多生理反应与两条相反的途径相关：（1）由血管紧张素转换酶（ACE）、血管紧张素II（Ang II）和血管紧张素1型（AT1）受体形成的经典途径，其与血管收缩、细胞增殖、器官肥大、钠潴留和醛固酮释放有关；（2）一种包括血管紧张素转换酶2（ACE2）、血管紧张素-（1-7）[Ang-（1-7）]和Mas受体的反调节或血管舒张途径，其参与血管舒张、抗增殖、抗肥大、心脏保护和肾脏保护作用。
本综述旨在更新体育锻炼与RAS血管舒张轴（ACE2-Ang-（1-7）-Mas受体轴）之间的相互作用。我们还研究了急性和慢性运动与血压调节以及RAS血管舒张轴各组成部分之间的关系。
我们在PUBMED、LILACS和IBECS中检索了动物模型和人类研究。
实验研究表明，体育锻炼可刺激ACE2-Ang-（1-7）-Mas受体轴，同时抑制ACE-Ang II-AT1受体途径。然而，到目前为止，尚未在人类中研究反调节RAS轴与体育锻炼之间的相互作用。
ACE2-Ang-（1-7）-Mas受体轴的激活可能在实验模型中体育锻炼的有益作用中发挥作用。有必要对人类进行进一步研究。
