Andronova V L, Grokhovskiĭ S L, Deriabin P G, Gurskiĭ G V, Galegov G A, L'vov D K
Vopr Virusol. 2012 Jul-Aug;57(4):24-6.
Two dimeric netropsin derivatives (Lys-bis-Nt 15Lys-bis-Nt) were comprehensively tested for antiviral and toxic activity in cell cultures and laboratory animals. The two compounds were found to provide effective and selective inhibition of reproduction of herpes simplex I both in cell culture Vero E6 and in brain of infected white mice, thereby increasing the survival rate and mean life expectation of treated animals as compared to control.
对两种二聚体鱼精蛋白衍生物(Lys-双-Nt 15Lys-双-Nt)在细胞培养物和实验动物中进行了抗病毒和毒性活性的全面测试。发现这两种化合物在细胞培养物Vero E6和感染的白色小鼠大脑中均能有效且选择性地抑制单纯疱疹I型的繁殖,从而与对照组相比提高了治疗动物的存活率和平均预期寿命。