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[在实验动物实验中测试的纺锤菌素衍生物的抗疱疹活性]

[Antiherpetic activity of netropsin derivatives as tested in experiments in laboratory animals].

作者信息

Andronova V L, Grokhovskiĭ S L, Deriabin P G, Gurskiĭ G V, Galegov G A, L'vov D K

出版信息

Vopr Virusol. 2012 Jul-Aug;57(4):24-6.

Abstract

Two dimeric netropsin derivatives (Lys-bis-Nt 15Lys-bis-Nt) were comprehensively tested for antiviral and toxic activity in cell cultures and laboratory animals. The two compounds were found to provide effective and selective inhibition of reproduction of herpes simplex I both in cell culture Vero E6 and in brain of infected white mice, thereby increasing the survival rate and mean life expectation of treated animals as compared to control.

摘要

对两种二聚体鱼精蛋白衍生物(Lys-双-Nt 15Lys-双-Nt)在细胞培养物和实验动物中进行了抗病毒和毒性活性的全面测试。发现这两种化合物在细胞培养物Vero E6和感染的白色小鼠大脑中均能有效且选择性地抑制单纯疱疹I型的繁殖,从而与对照组相比提高了治疗动物的存活率和平均预期寿命。

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