Andronova V L, Aleksandrova L A, Karpenko I L, Skoblov Iu S
D. I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, Moscow.
Antibiot Khimioter. 2003;48(5):3-6.
It was demonstrated that several 5'-phosphonates of 4'-thio-5-ethyl-2'-deoxyuridine possessed antiviral activity in vitro and in the murine model of herpes simplex virus type 1 infection. It was shown that the derivatives after intraabdominal administration penetrated effectively into the brain tissue. The agents provided statistically significant increase of the average life span, lower virus titre in the brain and lower lethality when compared to the control group of the animals. It is emphasized that the derivatives were less toxic than the original compound.
已证明，4'-硫代-5-乙基-2'-脱氧尿苷的几种5'-膦酸酯在体外以及在单纯疱疹病毒1型感染的小鼠模型中具有抗病毒活性。结果表明，腹腔给药后的衍生物能有效渗透到脑组织中。与动物对照组相比，这些药物使平均寿命有统计学意义的增加，降低了脑中的病毒滴度并降低了致死率。需要强调的是，这些衍生物的毒性低于原始化合物。
