[Racium植物药抗焦虑活性及安全性的临床前研究]

[Preclinical study of anxiolytic activity and safety of Racium phytomedicine].

作者信息

Kravchenko E V, Nasek V M, Ponteleeva I V, Mazhar M V, Sholomitskaia E Iu, Zhukova I A, San'ko E V, Veselukha O V, Nekhai A S, Shafranovskaia E V, Zhebrakova I V

出版信息

Eksp Klin Farmakol. 2012;75(8):21-4.

PMID:23012991

Abstract

Results of a preclinical study of the anxiolytic activity and safety of original Racium phytomedicine are presented. The preparation possessed high anxiolytic activity, exhibits a wide range of therapeutic effects, produces no lethality in male and female rats and mice upon single intragastric and intraperitoneal introduction in doses up to 5 g/kg (VI class of toxicity according to OECD), induces no pathologic effects upon prolonged (120 days) administration in these rodents, and has no local irritant and/or allergen action.

摘要

本文介绍了原创植物药Racium抗焦虑活性和安全性的临床前研究结果。该制剂具有高抗焦虑活性，表现出广泛的治疗效果，在雄性和雌性大鼠及小鼠单次灌胃和腹腔注射高达5 g/kg的剂量时（根据经合组织毒性分类为VI类）无致死性，在这些啮齿动物中长期（120天）给药不产生病理影响，且无局部刺激和/或过敏作用。