两种巴西南部西番莲属植物喷雾干燥粉末的抗焦虑活性评估。
Evaluation of anxiolytic activity of spray dried powders of two South Brazilian Passiflora species.
作者信息
Reginatto Flávio H, De-Paris Fernanda, Petry Raquel D, Quevedo João, Ortega George González, Gosmann Grace, Schenkel Eloir P
机构信息
Faculdade de Farmácia, Universidade Federal do Rio Grande do Sul, Porto Alegre, RS, Brazil.
出版信息
Phytother Res. 2006 May;20(5):348-51. doi: 10.1002/ptr.1853.
The Passiflora extracts have been used in folk medicine because of its reputed sedative and anxiolytic properties. The present study aimed to compare the potential anxiolytic activity of two Passiflora spray-dried powders obtained from P. alata and P. edulis, known in Brazil as 'maracujá'. Male adult Swiss rats were treated with 200, 400 and 800 mg/kg of spray-dried powders p.o. and anxiolytic activity was evaluated using the elevated plus-maze test. The spray-dried powders showed anxiolytic activity in doses of 400 and 800 mg/kg. Our results support the potential anxiolytic effect of Passiflora spray-dried powders (P. alata and P. edulis).
西番莲提取物因其具有镇静和抗焦虑特性而被用于民间医学。本研究旨在比较从翅茎西番莲和可食用西番莲（在巴西被称为“maracujá”）获得的两种西番莲喷雾干燥粉末的潜在抗焦虑活性。成年雄性瑞士大鼠经口给予200、400和800mg/kg的喷雾干燥粉末，使用高架十字迷宫试验评估抗焦虑活性。喷雾干燥粉末在400和800mg/kg剂量下表现出抗焦虑活性。我们的结果支持西番莲喷雾干燥粉末（翅茎西番莲和可食用西番莲）的潜在抗焦虑作用。
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