帕比培南酸的合成：串联链延伸-酰化反应的应用。
Syntheses of papyracillic acids: application of the tandem chain extension-acylation reaction.
机构信息
Department of Chemistry, University of New Hampshire, Durham, New Hampshire 03824, USA.
出版信息
J Org Chem. 2012 Oct 19;77(20):9171-8. doi: 10.1021/jo3017617. Epub 2012 Oct 5.
Abstract
A synthetic approach to the papyracillic acid family of natural products has been developed. The spiroacetal core is rapidly assembled through an unprecedented zinc carbenoid-mediated tandem chain extension-acylation reaction. Subsequent functional group manipulation provided access to papyracillic acid B and 4-epi-papyracillic acid C. The successful preparation of these molecules resulted in the clarification of structural assignments of members of this family of natural products.
摘要
已经开发出一种合成法来制备盘菌酸族天然产物。通过前所未有的锌卡宾介导的串联链延伸-酰化反应，快速组装了螺缩醛核心。随后的官能团操作提供了获得盘菌酸 B 和 4-差向盘菌酸 C 的途径。这些分子的成功制备澄清了该族天然产物成员的结构归属。
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