Horita H, Hoashi E, Okuyama Y, Kumagai K, Endo S
Folia Psychiatr Neurol Jpn. 1979;33(3):268-77.
The influence of hormone therapy on sleep states, pulse, respiration and seizure activities of infantile spasms was examined by means of overnight sleep polygraphy. Also the correlation between the changes of these parameters and the prognosis was investigated. The results were as follows: 1) In all cases, the awake time of TIB during hormone therapy was longer than before hormone therapy. The reduction of REM sleep time of SPT and lowering of REM density were remarkable during hormone therapy in cases with delayed psychomotor development as compared with cases with a considerable degree of psychomotor development. During hormone therapy, the NREM sleep time of SPT was shortened in cases with ACTH therapy, and prolonged in case with hydrocortisone therapy. 2) During hormone therapy, the pulse rate increased significantly in cases with a considerable degree of psychomotor development, but decreased significantly in cases with delayed psychomotor development. The change of respiratory rate by hormone therapy was not remarkable in all cases. 3) In cases with hypsarhythmic EEG records, the number of spikes decreased drastically by hormone therapy. In the case with EEG record of focal spikes, the number of spikes increased by hormone therapy. From the results mentioned above, the mechanism for effectiveness of hormone therapy and correlation between the administration of hormone therapy and prognosis was discussed.
通过夜间睡眠多导记录法研究了激素疗法对婴儿痉挛症的睡眠状态、脉搏、呼吸及癫痫发作活动的影响。同时还研究了这些参数变化与预后之间的相关性。结果如下：1）在所有病例中，激素治疗期间总睡眠时间（TIB）的清醒时间长于激素治疗前。与精神运动发育程度较好的病例相比，精神运动发育迟缓的病例在激素治疗期间快速眼动睡眠（REM）睡眠时间缩短及REM睡眠密度降低更为明显。在激素治疗期间，促肾上腺皮质激素（ACTH）治疗的病例中，短程睡眠图（SPT）的非快速眼动睡眠（NREM）睡眠时间缩短，而氢化可的松治疗的病例中则延长。2）在激素治疗期间，精神运动发育程度较好的病例脉搏率显著增加，而精神运动发育迟缓的病例则显著降低。激素疗法对呼吸频率的改变在所有病例中均不明显。3）在脑电图（EEG）记录为高度节律失调的病例中，激素治疗后棘波数量急剧减少。在EEG记录为局灶性棘波的病例中，激素治疗后棘波数量增加。根据上述结果，讨论了激素疗法有效的机制以及激素疗法的应用与预后之间的相关性。
