Fukuyama Y, Shionaga A, Iida Y
Eur Neurol. 1979;18(5):302-11. doi: 10.1159/000115094.
The whole night EEG were polygraphically recorded and analyzed in 9 patients with infantile spasms prior to ACTH therapy. The subjects were divided into two groups, favorable and unfavorable, depending upon the response to the ACTH therapy. (1) Among the unfavorable group, the deep sleep stage was not observed; while the light sleep stage tended to dominate. (2) REM sleep period was noted less among the unfavorable than among the favorable group. REM density also tended to be lower among the unfavorable group. (3) Of the 4 unfavorable cases, 2 did not manifest REM sleep at all. Of the remaining 2, 1 had a remarkably long REM interval period. Even among the favorable cases, REM sleep tended to be short and appear frequently. (4) The period of muscle atonia during NREM sleep was markedly prolonged in all cases. (5) Body movements of both types (gross and twitch) were less frequent comparing to those of normal younger children, more remarkably in unfavorable cases. From the above findings, a disorder of the pontine reticular formation would be suggested in cases of infantile spasms. Reduction of body movements at each sleep stage might indicate abnormalities of monoamine metabolism in the brain stem of patients with this condition.
对9例婴儿痉挛症患者在接受促肾上腺皮质激素（ACTH）治疗前进行了整晚的多导脑电图记录和分析。根据对ACTH治疗的反应，将受试者分为两组，反应良好组和反应不佳组。（1）在反应不佳组中，未观察到深度睡眠阶段；浅睡眠阶段占主导。（2）反应不佳组的快速眼动（REM）睡眠期比反应良好组少。反应不佳组的REM密度也往往较低。（3）在4例反应不佳的病例中，2例根本没有出现REM睡眠。在其余2例中，1例的REM间隔期明显延长。即使在反应良好的病例中，REM睡眠也往往较短且频繁出现。（4）在所有病例中，非快速眼动（NREM）睡眠期间的肌肉张力缺失期明显延长。（5）与正常幼儿相比，两种类型（大幅度和抽搐）的身体运动都较少，在反应不佳的病例中更明显。根据上述发现，婴儿痉挛症病例可能提示脑桥网状结构紊乱。每个睡眠阶段身体运动的减少可能表明这种疾病患者脑干中单胺代谢异常。
