Paap C M, Nahata M C
College of Pharmacy, Ohio State University, Columbus 43210.
Am J Hosp Pharm. 1990 Jan;47(1):147-50.
The stability of cefotaxime sodium at room and body temperatures in peritoneal dialysis solutions containing 1.5% or 4.25% dextrose was determined. Cefotaxime sodium 2 g was added to three 2-L bags of dialysis solution containing 1.5% dextrose, and cefotaxime sodium 500 mg was added to three 500-mL bags of dialysis solution containing 4.25% dextrose. The bags were stored at 25 or 37 degrees C Samples from bags stored at 25 degrees C were drawn aseptically at 0, 12, 24, 48, and 72 hours, and samples from bags stored at 37 degrees C were drawn at 0, 6, 12, and 24 hours. The pH of each sample was determined, and the cefotaxime concentration was measured by a stability-indicating high-performance liquid chromatographic method. At 37 degrees C the initial mean cefotaxime concentration declined to 97.9% at six hours, 89.1% at 12 hours, and 68.8% at 24 hours in the 1.5% dextrose solution; the mean percentages remaining in the solution containing 4.25% dextrose were 96.4%, 86.1%, and 71.0% at 6, 12, and 24 hours, respectively. At 25 degrees C the initial cefotaxime concentration declined to 92.4%, 84.4%, and 74.2% at 24, 48, and 72 hours, respectively, in 1.5% dextrose solution and to 92.0%, 84.3%, and 80.3% at 24, 48, and 72 hours, respectively, in 4.25% dextrose solution. In both solutions, cefotaxime concentration decreased by more than 10% at and after 12 hours at 37 degrees C and between 24 and 48 hours at 25 degrees C.(ABSTRACT TRUNCATED AT 250 WORDS)
测定了头孢噻肟钠在含1.5%或4.25%葡萄糖的腹膜透析液中于室温和体温下的稳定性。将2g头孢噻肟钠加入三袋2L含1.5%葡萄糖的透析液中，将500mg头孢噻肟钠加入三袋500mL含4.25%葡萄糖的透析液中。透析袋分别储存于25℃或37℃。在25℃储存的透析袋中的样品于0、12、24、48和72小时无菌抽取，在37℃储存的透析袋中的样品于0、6、12和24小时抽取。测定每个样品的pH值，并用稳定性指示高效液相色谱法测量头孢噻肟浓度。在37℃时，1.5%葡萄糖溶液中头孢噻肟的初始平均浓度在6小时降至97.9%，12小时降至89.1%，24小时降至68.8%；在含4.25%葡萄糖的溶液中，6、12和24小时剩余的平均百分比分别为96.4%、86.1%和71.0%。在25℃时，1.5%葡萄糖溶液中头孢噻肟的初始浓度在24、48和72小时分别降至92.4%、84.4%和74.2%，在4.25%葡萄糖溶液中分别降至92.0%、84.3%和80.3%。在两种溶液中，头孢噻肟浓度在37℃时12小时及之后以及在25℃时24至48小时下降超过10%。（摘要截短于250字）
