Kane M P, Bailie G R, Moon D G, Siu I
Department of Pharmacy Practice, Albany College of Pharmacy, Union University, NY 12208.
Am J Hosp Pharm. 1994 Feb 1;51(3):373-7.
The stability of ciprofloxacin 25 mg/L in peritoneal dialysis solutions containing 1.5% and 4.25% dextrose after storage at 4 degrees C for two weeks, 25 degrees C for one week, or 37 degrees C for two days was evaluated. Ciprofloxacin 50 mg was added to 18 2-L bags of peritoneal dialysis solutions, nine containing 1.5% dextrose and nine containing 4.25% dextrose. Three bags of each dialysis solution were stored at 4 degrees C for 14 days, 25 degrees C for 7 days, and 37 degrees C for 2 days. Samples were drawn from each bag, and ciprofloxacin concentrations were measured by high-performance liquid chromatography. Stability was defined as less than 10% decrease from initial concentration. In the solution containing 1.5% dextrose, 87.2% of the ciprofloxacin remained after 14 days of storage at 4 degrees C, 93.4% remained after 7 days of storage at 25 degrees C, and 95.2% remained after 2 days of storage at 37 degrees C. In the solution containing 4.25% dextrose, 89.0% of the ciprofloxacin remained after 14 days of storage at 4 degrees C, 93.7% remained after 7 days of storage at 25 degrees C, and 97.8% remained after 2 days of storage at 37 degrees C. In peritoneal dialysis solutions containing 1.5% and 4.25% dextrose, ciprofloxacin was stable for seven days at 25 degrees C and for 48 hours at 37 degrees C. Ciprofloxacin concentrations after two weeks at 4 degrees C were below 90% of initial concentration.
评估了25毫克/升环丙沙星在含1.5%和4.25%葡萄糖的腹膜透析液中，于4℃储存两周、25℃储存一周或37℃储存两天后的稳定性。将50毫克环丙沙星加入18袋2升的腹膜透析液中，其中9袋含1.5%葡萄糖，9袋含4.25%葡萄糖。每种透析液的三袋分别在4℃储存14天、25℃储存7天、37℃储存2天。从每袋中取样，通过高效液相色谱法测定环丙沙星浓度。稳定性定义为浓度较初始浓度降低少于10%。在含1.5%葡萄糖的溶液中，4℃储存14天后87.2%的环丙沙星留存，25℃储存7天后93.4%留存，37℃储存2天后95.2%留存。在含4.25%葡萄糖的溶液中，4℃储存14天后89.0%的环丙沙星留存，25℃储存7天后93.7%留存，37℃储存2天后97.8%留存。在含1.5%和4.25%葡萄糖的腹膜透析液中，环丙沙星在25℃下稳定7天，在37℃下稳定48小时。4℃储存两周后的环丙沙星浓度低于初始浓度的90%。
