Department of Obstetrics and Gynecology, New York Presbyterian Hospital-Weill Cornell Medical Center, New York, NY 10021, USA.
J Perinatol. 2012 Oct;32(10):807-9. doi: 10.1038/jp.2011.172.
A 41-year-old pregnant African-American woman noticed rapid growth of her cesarean delivery skin scar beginning at 14-week gestation. Skin biopsy, which was performed at 31 weeks, revealed poorly differentiated cutaneous melanoma. At 34 weeks, she underwent repeat cesarean delivery with tumor excision, pelvic lymphadenectomy and abdominal wall reconstruction. Locally advanced disease and anatomical limitations prevented attainment of negative surgical margins. Despite adjuvant chemotherapy and radiation, she died 1 year after diagnosis. Deferring biopsy of a suspicious skin lesion during pregnancy may have delayed the diagnosis of melanoma in this case and possibly affected the long-term outcome.
一位 41 岁的怀孕非洲裔美国妇女在怀孕 14 周时注意到剖宫产皮肤瘢痕迅速生长。31 周时进行的皮肤活检显示为低分化皮肤黑色素瘤。34 周时，她接受了重复剖宫产术，同时切除肿瘤、盆腔淋巴结清扫和腹壁重建。局部晚期疾病和解剖学限制使手术切缘无法达到阴性。尽管进行了辅助化疗和放疗，但她在诊断后 1 年死亡。在怀孕期间对可疑皮肤病变进行活检可能会延迟黑色素瘤的诊断，并且可能会影响长期预后。
