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Tareciliosides N-S:纤细桐叶中的又一类环阿尔廷烷型甾体皂苷,以及皂苷和三萜的细胞毒性。

Tareciliosides N-S: further cycloartane saponins from the leaves of Tarenna gracilipes, and cytotoxicity of saponins and triterpenes.

机构信息

Department of Pharmacognosy, Graduate School of Biomedical Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

出版信息

J Nat Med. 2013 Jul;67(3):503-11. doi: 10.1007/s11418-012-0707-2. Epub 2012 Sep 27.

Abstract

Six cycloartane glycosides, named tareciliosides N-S, and a known iridoid glucoside, ixoroside, were isolated in further extensive studies on the 1-BuOH-soluble fraction of a MeOH extract of the leaves of Tarenna gracilipes. From the EtOAc-soluble fraction, three known triterpenes were isolated. Their toxicities toward A549 and Leishmania major trypanosome protozoa were assayed. Triterpenes were selectively active in the two organisms.

摘要

在对台湾省肖楠叶甲醇提取物的 1-BuOH 可溶部分进行进一步的广泛研究中,分离得到了六种环阿屯烷糖苷,命名为塔雷西利奥糖苷 N-S,以及一种已知的裂环烯醚萜苷,伊克索苷。从 EtOAc 可溶部分分离得到三种已知的三萜。测定了它们对 A549 和利什曼原虫原生动物的毒性。三萜类化合物在这两种生物中具有选择性活性。

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