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石竹皂苷G - I、三萜皂苷、邻氨基苯甲酸酰胺糖苷及黄酮糖苷,来自日本石竹地上部分及其细胞毒性

Dianthosaponins G-I, triterpene saponins, an anthranilic acid amide glucoside and a flavonoid glycoside from the aerial parts of Dianthus japonicus and their cytotoxicity.

作者信息

Kanehira Yuka, Kawakami Susumu, Sugimoto Sachiko, Matsunami Katsuyoshi, Otsuka Hideaki

机构信息

Department of Pharmacognosy, Graduate School of Biomedical and Health Sciences, Hiroshima University, 1-2-3 Kasumi, Minami-ku, Hiroshima, 734-8553, Japan.

Department of Natural Product Chemistry, Faculty of Pharmacy, Yasuda Women's University, 6-13-1 Yasuhigashi, Asaminami-ku, Hiroshima, 731-0153, Japan.

出版信息

J Nat Med. 2016 Oct;70(4):816-24. doi: 10.1007/s11418-016-1019-8. Epub 2016 Jun 28.

Abstract

Extensive isolation work on the 1-BuOH-soluble fraction of a MeOH extract of the aerial parts of Dianthus japonicus afforded three further triterpene glycosyl estsers, termed dianthosaponins G-I, an anthranilic acid amide glucoside and a C-glycosyl flavonoid along with one known triterpene saponin. Their structures were elucidated from spectroscopic evidence. The cytotoxicity of the isolated compounds toward A549 cells was evaluated.

摘要

对日本石竹地上部分甲醇提取物的正丁醇可溶部分进行了广泛的分离工作,得到了另外三种三萜糖苷酯,即石竹皂苷G - I、一种邻氨基苯甲酸酰胺葡萄糖苷和一种C - 糖基黄酮,以及一种已知的三萜皂苷。通过光谱证据阐明了它们的结构。评估了分离出的化合物对A549细胞的细胞毒性。

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