脊椎动物神经发育和功能中的 Wnt 信号传导。
Wnt signaling in vertebrate neural development and function.
机构信息
Department of Psychiatry, University of California, San Francisco, San Francisco, CA 94158, USA.
出版信息
J Neuroimmune Pharmacol. 2012 Dec;7(4):774-87. doi: 10.1007/s11481-012-9404-x. Epub 2012 Sep 27.
Abstract
Members of the Wnt family of secreted signaling proteins influence many aspects of neural development and function. Wnts are required from neural induction and axis formation to axon guidance and synapse development, and even help modulate synapse activity. Wnt proteins activate a variety of downstream signaling pathways and can induce a similar variety of cellular responses, including gene transcription changes and cytoskeletal rearrangements. This review provides an introduction to Wnt signaling pathways and discusses current research on their roles in vertebrate neural development and function.
摘要
Wnt 家族的分泌信号蛋白成员影响神经发育和功能的许多方面。从神经诱导和轴形成到轴突导向和突触发育，Wnts 都是必需的，甚至有助于调节突触活动。Wnt 蛋白激活多种下游信号通路，并能诱导类似的多种细胞反应，包括基因转录变化和细胞骨架重排。本文介绍了 Wnt 信号通路，并讨论了它们在脊椎动物神经发育和功能中的作用的最新研究进展。
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