Graduate Program in Biomechanics and Movement Science, University of Delaware, Newark, Delaware, and King Saud University, Riyadh, Saudi Arabia.
Sports Health. 2012 Jul;4(4):284-92. doi: 10.1177/1941738112445726.
Muscle impairments associated with knee osteoarthritis (OA) are the primary underlying cause of functional limitations. Understanding the extent of muscle impairments, its relationship with physical function and disease progression, and the evidence behind exercise therapy that targets muscle impairments is crucial.
An electronic search for relevant articles using MEDLINE and CINHAL databases up to September 2011 was performed. In addition to the electronic search, retrieved articles were searched manually for relevant studies.
Quadriceps, hamstrings, and hip muscles are significantly impaired in subjects with knee OA compared with age-matched controls. Muscle strength, especially quadriceps, is a major determinant of both performance-based and self-reported physical function. Whether stronger quadriceps is protective against knee OA onset and progression is not clear. Exercise therapy, including global and targeted resistance training, is effective in reducing pain and improving function in subjects with knee OA.
Subjects with knee OA have significant muscle impairments. These muscle impairments affect physical function and should be targeted in therapy. Further research is needed to explore the relationship between quadriceps strength and knee OA initiation and progression and to determine the optimal exercise prescription that augments outcomes in this patient population.
与膝骨关节炎（OA）相关的肌肉功能障碍是导致功能受限的主要潜在原因。了解肌肉功能障碍的严重程度、它与身体功能和疾病进展的关系，以及针对肌肉功能障碍的运动疗法的证据至关重要。
使用 MEDLINE 和 CINHAL 数据库对截至 2011 年 9 月的相关文章进行了电子检索。除了电子检索外，还对检索到的文章进行了手动搜索，以寻找相关研究。
与年龄匹配的对照组相比，膝骨关节炎患者的股四头肌、腘绳肌和髋部肌肉明显受损。肌肉力量，尤其是股四头肌，是决定基于表现和自我报告的身体功能的主要因素。更强的股四头肌是否能预防膝骨关节炎的发生和进展尚不清楚。运动疗法，包括全身和针对性的抗阻训练，在膝骨关节炎患者中有效减轻疼痛和改善功能。
膝骨关节炎患者存在明显的肌肉功能障碍。这些肌肉功能障碍会影响身体功能，应该在治疗中加以解决。需要进一步研究来探讨股四头肌力量与膝骨关节炎起始和进展的关系，并确定增强该患者群体治疗效果的最佳运动方案。
