Pang Xiaohui, Liu Ming, Bi Feng
Laboratory of Signal Transduction & Molecular Targeted Therapy/Department of Medical Oncology, West China Hospital, Sichuan University, Chengdu 610041, China.
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi. 2012 Aug;29(4):780-3, 802.
MicroRNAs, known as small noncoding MiRNAs, 19 to 24 nt in length, are important gene regulators and recognized as key players in carcinogenesis. The mechanism lies in that the MiRNAs can conjugate with their targeted mRNA and then lead to the targeted mRNA degradation or repress their translation. Bioinformatic analysis indicates that each MiRNA can regulate hundreds of gene targets and could serve functionally as "oncogenes" or "tumor suppressor genes", and therefore regulate multiple cellular processes relevant to carcinogenesis and cancer progression. Up to now, there have been a lot of studies about the MiRNAs which may play an important role in stomach neoplasms. The purpose of this paper is to have a review of the present studies on the MiRNAs related to stomach neoplasms, in order set basis for further study and their clinical application.
微小RNA（MicroRNAs），即长度为19至24个核苷酸的小型非编码RNA，是重要的基因调节因子，被认为是致癌过程中的关键参与者。其机制在于，微小RNA可与它们的靶标信使核糖核酸（mRNA）结合，进而导致靶标mRNA降解或抑制其翻译。生物信息学分析表明，每个微小RNA可调控数百个基因靶标，在功能上可作为“癌基因”或“肿瘤抑制基因”，从而调节与致癌作用和癌症进展相关的多个细胞过程。到目前为止，已经有很多关于微小RNA在胃肿瘤中可能发挥重要作用的研究。本文的目的是对目前有关胃肿瘤相关微小RNA的研究进行综述，以便为进一步研究及其临床应用奠定基础。
