Department of Neurological Surgery, University of California-Davis School of Medicine, Sacramento, CA 95817, USA.
J Neurotrauma. 2013 Jan 15;30(2):131-9. doi: 10.1089/neu.2012.2646.
More than 5,000,000 survivors of traumatic brain injury (TBI) live with persistent cognitive deficits, some of which likely derive from hippocampal dysfunction. Oscillatory activity in the hippocampus is critical for normal learning and memory functions, and can be modulated using deep brain stimulation techniques. In this pre-clinical study, we demonstrate that lateral fluid percussion TBI results in the attenuation of hippocampal theta oscillations in the first 6 days after injury, which correlate with deficits in the Barnes maze spatial working memory task. Theta band stimulation of the medial septal nucleus (MSN) results in a transient increase in hippocampal theta activity, and when delivered 1 min prior to training in the Barnes maze, it significantly improves spatial working memory. These results suggest that MSN theta stimulation may be an effective neuromodulatory technique for treatment of persistent learning and memory deficits after TBI.
超过 500 万创伤性脑损伤 (TBI) 幸存者存在持续的认知缺陷，其中一些可能源于海马功能障碍。海马的振荡活动对正常的学习和记忆功能至关重要，并且可以使用深部脑刺激技术进行调节。在这项临床前研究中，我们证明外侧液击 TBI 导致损伤后前 6 天海马θ振荡的衰减，这与巴恩斯迷宫空间工作记忆任务的缺陷相关。内侧隔核 (MSN) 的θ带刺激导致海马θ活动的短暂增加，并且当在巴恩斯迷宫训练前 1 分钟给予时，它显著改善了空间工作记忆。这些结果表明，MSN θ刺激可能是治疗 TBI 后持续学习和记忆缺陷的有效神经调节技术。
