外侧液压冲击伤后海马θ功能障碍。
Hippocampal θ dysfunction after lateral fluid percussion injury.
机构信息
Department of Neurological Surgery, University of California-Davis, Davis, California 95618, USA.
出版信息
J Neurotrauma. 2010 Sep;27(9):1605-15. doi: 10.1089/neu.2010.1370.
Abstract
Chronic memory deficits are a major cause of morbidity following traumatic brain injury (TBI). In the rat, the hippocampal theta rhythm is a well-studied correlate of memory function. This study sought to investigate disturbances in hippocampal theta rhythm following lateral fluid percussion injury in the rat. A total of 13 control rats and 12 TBI rats were used. Electrodes were implanted in bilateral hippocampi and an electroencephalogram (EEG) was recorded while the rats explored a new environment, and also while navigating a modified version of the Barnes maze. Theta power and peak theta frequency were significantly attenuated in the injured animals. Further, injured rats were less likely to develop a spatial strategy for Barnes maze navigation compared to control rats. In conclusion, rats sustaining lateral fluid percussion injury demonstrated deficits in hippocampal theta activity. These deficits may contribute to the underlying memory problems seen in chronic TBI.
摘要
慢性记忆缺陷是创伤性脑损伤（TBI）后发病率的主要原因。在大鼠中，海马θ节律是记忆功能的一个研究得很好的相关物。本研究旨在调查大鼠侧脑室液压冲击损伤后海马θ节律的紊乱。共使用了 13 只对照大鼠和 12 只 TBI 大鼠。在大鼠探索新环境时以及在改良版 Barnes 迷宫中导航时，在双侧海马植入电极并记录脑电图（EEG）。损伤动物的θ功率和峰值θ频率明显降低。此外，与对照大鼠相比，受伤大鼠更不可能为 Barnes 迷宫导航制定空间策略。总之，承受侧脑室液压冲击损伤的大鼠表现出海马θ活动不足。这些缺陷可能是慢性 TBI 中所见记忆问题的基础。
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