Department of Neurobiology, Care Sciences and Society, Division of Physiotherapy, Karolinska Institute, Huddinge, Sweden.
BMC Neurol. 2012 Sep 27;12:111. doi: 10.1186/1471-2377-12-111.
There is increasing scientific knowledge about the interaction between physiological (musculoskeletal, neuromuscular, cognitive and sensory) systems and their influence on balance and walking impairments in Parkinson's disease. We have developed a new conceptual framework for balance training, emphasising specific components of balance control related to Parkinson's disease symptoms by using highly challenging, progressive and varying training conditions. The primary aim of this proposed randomised controlled trial will be to investigate the short-term and long-term effects of a 10-week balance training regime in elderly with Parkinson's disease.
METHODS/DESIGN: Eighty participants with mild to moderate idiopathic Parkinson's disease will be recruited and randomly allocated to an intervention group receiving balance training or a control group whose participants will continue to receive their usual care. The intervention will consist of a 10-week group training regime (1-hour training, three times per week), which will be led by two physiotherapists to ensure training progression and safety. The conceptual framework will be applied by addressing specific balance components (sensory integration, anticipatory postural adjustments, motor agility, stability limits) through varying training conditions and structured progression. Assessment will be conducted through a multi-dimensional battery of outcomes, prior to and immediately after the 10-week intervention, and at 9 and 15 months' follow-up after entering the study. Primary outcome measures will be balance performance (assessed using the Mini Balance Evaluation Systems Test), change in gait velocity (m/s) between single and dual task walking, and fear of falling (evaluated using the Fall Efficacy Scale International).
This study has the potential to provide new insight and knowledge of the effects of specific, varied and challenging balance training on a wide health spectrum in elderly with PD. If found to be effective, this pragmatic approach with translation of theory into practice, can be implemented in existing outpatient care.
NCT01417598.
越来越多的科学知识涉及到生理（肌肉骨骼、神经肌肉、认知和感觉）系统之间的相互作用及其对帕金森病患者平衡和行走障碍的影响。我们开发了一种新的平衡训练概念框架，通过使用极具挑战性、渐进性和多变的训练条件，强调与帕金森病症状相关的平衡控制特定成分。本研究旨在探讨一项为期 10 周的平衡训练方案对老年帕金森病患者的短期和长期影响。
方法/设计：将招募 80 名轻度至中度特发性帕金森病患者，并将其随机分配到干预组（接受平衡训练）或对照组（参与者继续接受常规护理）。干预措施包括为期 10 周的小组训练方案（每周 3 次，每次 1 小时），由两名物理治疗师进行，以确保训练进展和安全性。该概念框架将通过应用变化的训练条件和结构化进展来解决特定的平衡成分（感觉整合、预期姿势调整、运动敏捷性、稳定性极限）。评估将在 10 周干预之前和之后，以及进入研究后 9 个月和 15 个月进行，通过多维结果测试进行。主要观察指标为平衡表现（使用 Mini Balance Evaluation Systems Test 评估）、单任务和双任务行走时的步态速度变化（m/s）和跌倒恐惧（使用国际跌倒效能量表评估）。
这项研究有可能提供新的见解和知识，了解特定、多变和具有挑战性的平衡训练对老年帕金森病患者广泛健康状况的影响。如果被证明有效，这种具有理论转化为实践的实用方法，可以在现有的门诊护理中实施。
NCT01417598。
