Dermatology, Faculty of Medicine Siriraj Hospital, Bangkok, Thailand.
Photodermatol Photoimmunol Photomed. 2012 Aug;28(4):181-6. doi: 10.1111/j.1600-0781.2012.00662.x.
Hypopigmented mycosis fungoides (MF) is an uncommon variant of MF. It is rare in Caucasians but more common in young skin-of-color individuals. To date, there are only a few reports on UV-based treatment for this condition.
To analyze the efficacy of PUVA photochemotherapy and narrowband UVB (NBUVB) phototherapy for hypopigmented MF.
A retrospective study of nine patients who received PUVA or NBUVB was performed. The clinical response, total number of treatments, cumulative UV doses, disease-free interval and adverse effects were recorded.
Eight patients had stage IA and one patient had stage IB. Six patients received NBUVB and three patients received PUVA. Three patients (50%) in the NBUVB group and three patients (100%) in the PUVA group had complete response (CR). Total UV dose to get maximal clinical response ranged from 27.1-59.6 J/cm(2) in the NBUVB group and 244-669.1 J/cm(2) in the PUVA group. In six patients who had CR, recurrence was found in four (66.7%), and the disease-free interval ranged from 2 months to 6 years.
PUVA and NBUVB are effective for hypopigmented MF. Comparing between these two methods, PUVA provided a better response than NBUVB. Although the disease responded well to phototherapy, relapse was common.
色素减退型蕈样肉芽肿（MF）是 MF 的一种罕见变异。在白种人中很少见，但在年轻的有色人种中更为常见。迄今为止，关于这种疾病的 UV 为基础的治疗方法仅有少数报道。
分析补骨脂素加紫外线 A（PUVA）光化学疗法和窄谱中波紫外线（NBUVB）光疗治疗色素减退型 MF 的疗效。
对接受 PUVA 或 NBUVB 治疗的 9 例患者进行回顾性研究。记录临床反应、总治疗次数、累积 UV 剂量、无病间隔和不良反应。
8 例患者为 IA 期，1 例患者为 IB 期。6 例患者接受 NBUVB 治疗，3 例患者接受 PUVA 治疗。NBUVB 组 3 例（50%）和 PUVA 组 3 例（100%）患者完全缓解（CR）。NBUVB 组获得最大临床反应的总 UV 剂量为 27.1-59.6 J/cm(2)，PUVA 组为 244-669.1 J/cm(2)。在 6 例 CR 患者中，有 4 例（66.7%）复发，无病间隔为 2 个月至 6 年。
PUVA 和 NBUVB 对色素减退型 MF 有效。与两种方法相比，PUVA 比 NBUVB 提供了更好的反应。尽管疾病对光疗反应良好，但复发很常见。
