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多西他赛诱导的光幻视现象。

Docetaxel-induced photo-recall phenomenon.

机构信息

Department of Dermatology, Pontchaillou Hospital, Rennes, France.

出版信息

Photodermatol Photoimmunol Photomed. 2012 Aug;28(4):222-3. doi: 10.1111/j.1600-0781.2012.00669.x.

Abstract

Photo-recall phenomenon is a phototoxic eruption occurring on areas of previous ultraviolet-induced solar erythema following a systemic administration of a drug. It has been mostly described with methotrexate but remains rare with other antineoplastic drugs. We describe a case of docetaxel-induced photo-recall skin rash in a woman treated for a non-small-cell lung cancer. Although the patient has refused to receive a second infusion, chemotherapy can be carried on with photoprotection and the use of topical and/or systemic corticosteroids. In contrast, radiation recall is a well-known reaction by oncologists, most of them may not be aware of a similar phenomenon called photo-recall phenomenon. Recognizing this entity may avoid misdiagnosing a drug allergy and should avoid inappropriate decisions of drug discontinuation.

摘要

光化性回忆疹是一种光毒性发疹,在全身给予药物后,出现在先前紫外线诱导的太阳红斑区域。它主要与甲氨蝶呤相关,但在其他抗肿瘤药物中仍很少见。我们描述了一例多西他赛引起的光化性回忆性皮疹的病例,该患者正在接受非小细胞肺癌治疗。尽管患者拒绝接受第二次输注,但可以通过光保护以及使用局部和/或全身皮质类固醇进行化疗。相比之下,放射回忆是肿瘤学家熟知的一种反应,他们中的大多数可能不知道有一种类似的现象称为光化性回忆疹。认识到这一实体可以避免误诊为药物过敏,并应避免因药物停药而做出不当决定。

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