Instituto de Biología Molecular y Celular de Plantas, CSIC-UPV, Ingeniero Fausto Elio s/n, 46022 València, Spain.
Curr Opin Virol. 2012 Dec;2(6):719-24. doi: 10.1016/j.coviro.2012.09.004. Epub 2012 Sep 25.
The application in recent years of network theory methods to the study of host-virus interactions is providing a new perspective to the way viruses manipulate the host to promote their own replication. An integrated molecular model of such pathosystems require three detailed maps describing, firstly, the interactions between viral elements, secondly, the interactions between host elements, and thirdly, the cross-interactions between viral and host elements. Here, we compile available information for Potyvirus infecting Arabidopsis thaliana. With an integrated model, it is possible to analyze the mode of virus action and how the perturbation of the virus targets propagates along the network. These studies suggest that viral pathogenicity results not only from the alteration of individual elements but it is a systemic property.
近年来，网络理论方法在宿主-病毒相互作用研究中的应用为病毒操纵宿主以促进自身复制的方式提供了新的视角。这种病理系统的综合分子模型需要三个详细的图谱来描述，首先是病毒元素之间的相互作用，其次是宿主元素之间的相互作用，最后是病毒和宿主元素之间的交叉相互作用。在这里，我们编译了感染拟南芥的马铃薯 Y 病毒的可用信息。通过综合模型，可以分析病毒作用的模式以及病毒靶标的扰动如何沿着网络传播。这些研究表明，病毒的致病性不仅源于个别元素的改变，而且是一种系统性的特性。
