褪黑素受体激动剂治疗老年急性脑卒中后谵妄。
Melatonin receptor agonists for treating delirium in elderly patients with acute stroke.
机构信息
Department of Neuroendovascular Treatment, Shiroyama Hospital, Osaka, Japan.
出版信息
J Stroke Cerebrovasc Dis. 2013 Oct;22(7):1107-10. doi: 10.1016/j.jstrokecerebrovasdis.2012.08.012. Epub 2012 Sep 25.
BACKGROUND
Delirium is considered to worsen life prognosis in elderly patients with stroke. We examined the effects of the melatonin receptor agonist ramelteon for treating delirium in elderly stroke patients with insomnia in comparison to the other drugs.
METHODS
Elderly patients with delirium and insomnia after acute stroke who were treated with ramelteon (7 patients; mean age 76 years) and the other drugs (21 patients; mean age 77.3 years) between July 2011 and March 2012 at our hospital were retrospectively examined.
RESULTS
All patients treated with ramelteon had a significant improvement within a week and were started on early and aggressive rehabilitation. No patient experienced oversedation, neurologic deterioration, or any other worsening effect associated with ramelteon treatment.
CONCLUSIONS
Melatonin receptor agonists may be effective for the treatment of delirium in elderly patients with acute stroke.
背景
谵妄被认为会使老年脑卒中患者的预后恶化。我们研究了褪黑素受体激动剂雷美尔酮治疗伴有失眠的老年脑卒中谵妄患者的效果，并与其他药物进行了比较。
方法
回顾性分析了 2011 年 7 月至 2012 年 3 月在我院接受雷美尔酮（7 例；平均年龄 76 岁）和其他药物（21 例；平均年龄 77.3 岁）治疗的伴有急性脑卒中后谵妄和失眠的老年患者。
结果
所有接受雷美尔酮治疗的患者在一周内均有显著改善，并开始进行早期和积极的康复治疗。没有患者出现过度镇静、神经功能恶化或与雷美尔酮治疗相关的任何其他恶化。
结论
褪黑素受体激动剂可能对治疗老年急性脑卒中患者的谵妄有效。
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