Aronson S, Bender E, Feinstein S B, Heidenreich P H, Ellis J, Dick C, Roizen M F, Karp R B
Department of Anesthesia and Critical Care, University of Chicago, Illinois 60637.
Anesthesiology. 1990 Feb;72(2):295-301.
The ability of contrast echocardiography to assess regional myocardial perfusion during cardiopulmonary bypass in a dog model for coronary artery bypass surgery was evaluated. Sonicated Renograffin-76 microbubbles (meglumin diatrigoate and sodium diatrigoate) were injected into an aortic root proximal to an aortic occlusion clamp root while dogs were on cardiopulmonary bypass, with the heart arrested in diastole. Echocardiographic contrast-enhanced regions of myocardial perfusion were easily visualized. Differences in contrast-enhanced myocardial regions depended on coronary artery occlusion or patency. The contrast-enhanced images of myocardial perfusion showed that, for a given myocardial segment of the supplying vessel, the presence or absence of contrast effect reliably predicted vessel occlusion or patency (P less than .01). In the future contrast echocardiography may allow the direct assessment of regional myocardial perfusion in the operating room.
评估了在冠状动脉搭桥手术犬模型中，对比超声心动图在体外循环期间评估局部心肌灌注的能力。在犬体外循环期间，当心脏停搏于舒张期时，将超声处理的泛影葡胺-76微泡（泛影葡胺和泛影酸钠）注入靠近主动脉阻断钳根部的主动脉根部。心肌灌注的超声心动图对比增强区域很容易可视化。对比增强心肌区域的差异取决于冠状动脉闭塞或通畅情况。心肌灌注的对比增强图像显示，对于供应血管的给定心肌节段，对比效应的存在与否可可靠地预测血管闭塞或通畅（P小于0.01）。未来，对比超声心动图可能允许在手术室直接评估局部心肌灌注。
