Akasbi Yousra, Awada Ahmad, Arifi Samia, Mellas Nawfal, El Mesbahi Omar
Hassan II University Hospital, Medical Oncology Department, Morocco.
Bull Cancer. 2012 Oct;99(10):92-9. doi: 10.1684/bdc.2012.1636.
"Classic" Kaposi's sarcoma (CKS) not related to HIV is a multifocal angioproliferative neoplasm that is linked to human herpesvirus. CKS is a cutaneous cancer frequently occurring with an indolent course. However, it can compromise the quality of life by causing pain, disfigurement and functional disability. For this reason, the main treatment goals are not only to reduce the cutaneous lesions but also to alleviate organ involvement and psychological stress by delaying disease progression and ultimately cure. This report summarizes systemic treatment options of CKS, including chemotherapy, immunotherapy and anti-HHV8 therapy. In addition, this review will focus on the recent understanding of carcinogenesis and consequently highlight potential "targeted" therapeutic interventions.
与HIV无关的“经典型”卡波西肉瘤（CKS）是一种多灶性血管增殖性肿瘤，与人疱疹病毒有关。CKS是一种皮肤癌，通常病程较为缓慢。然而，它会导致疼痛、毁容和功能障碍，从而影响生活质量。因此，主要治疗目标不仅是减少皮肤病变，还包括通过延缓疾病进展并最终治愈来减轻器官受累和心理压力。本报告总结了CKS的全身治疗选择，包括化疗、免疫疗法和抗HHV8疗法。此外，本综述将聚焦于对致癌作用的最新认识，并因此突出潜在的“靶向”治疗干预措施。
