脂联素在慢性自发性荨麻疹的发病机制中起作用吗？
Does adiponectin play a role in the pathogenesis of chronic spontaneous urticaria?
作者信息
Adamczyk Katarzyna, Wcislo-Dziadecka Dominika, Zbiciak-Nylec Martyna, Brzezinska-Wcislo Ligia, Brzoza Zenon
机构信息
Department of Dermatology, School of Medicine in Katowice, Medical University of Silesia, Poland.
Department of Skin Structural Studies, Chair of Cosmetology, School of Pharmacy with Division of Laboratory Medicine in Sosnowiec, Medical University of Silesia, Poland.
出版信息
Cent Eur J Immunol. 2020;45(1):56-59. doi: 10.5114/ceji.2020.94678.
INTRODUCTION
Chronic spontaneous urticaria constitutes an interdisciplinary problem and its pathogenesis is still a subject of debate. Overweight and hyperlipidemia are supposed to be related to chronic spontaneous urticaria. Fatty tissue can be the source of adipokines.
AIM OF THE STUDY
To assess the potential role of adiponectin in chronic spontaneous urticaria pathogenesis.
MATERIAL AND METHODS
The study included 52 chronic spontaneous urticaria patients and 43 healthy controls. The patients were divided into two subgroups: patients with wheals only, and patients with urticaria and an accompanying angioedema. The adiponectin concentration was measured in all studied subjects.
RESULTS
No statistically significant difference in adiponectin level was determined between the studied groups and subgroups.
CONCLUSIONS
We are among the first to present the results of study to determine a possible role of adipokines in chronic spontaneous urticaria pathogenesis. We did not observe any difference in adiponectin level. In our opinion, it is necessary to conduct further analyses in this field.
引言
慢性自发性荨麻疹是一个跨学科问题，其发病机制仍存在争议。超重和高脂血症被认为与慢性自发性荨麻疹有关。脂肪组织可能是脂肪因子的来源。
研究目的
评估脂联素在慢性自发性荨麻疹发病机制中的潜在作用。
材料与方法
该研究纳入了52例慢性自发性荨麻疹患者和43例健康对照。患者被分为两个亚组：仅出现风团的患者，以及患有荨麻疹并伴有血管性水肿的患者。在所有研究对象中测量脂联素浓度。
结果
在研究组和亚组之间未确定脂联素水平存在统计学显著差异。
结论
我们是首批呈现研究结果以确定脂肪因子在慢性自发性荨麻疹发病机制中可能作用的研究团队之一。我们未观察到脂联素水平有任何差异。我们认为，有必要在该领域进行进一步分析。
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