Department of Neurology, Tohoku University Graduate School of Medicine, Aobaku, Sendai, Japan.
J Neuroimmunol. 2013 Jan 15;254(1-2):178-82. doi: 10.1016/j.jneuroim.2012.09.002. Epub 2012 Sep 25.
Complement is thought to play a pivotal role in neuromyelitis optica (NMO) pathogenesis. Anaphylatoxins (C3a, C4a, and C5a), produced in complement activation, have proinflammatory potential, and thereby may play an important role. We measured concentrations of anaphylatoxins in CSF and sera, obtained from patients with NMO (n=15), multiple sclerosis (MS) (n=15), and other neurological disease (OND) (n=12), and evaluated their clinical implications. The CSF-C5a levels were elevated significantly in NMO patients, especially in patients with multiple enhanced lesions on MRI. The CSF-C5a levels correlated with the severity of exacerbation. Our results may provide a rationale for anti-complement therapies of NMO.
补体被认为在视神经脊髓炎（NMO）发病机制中发挥关键作用。过敏毒素（C3a、C4a 和 C5a）在补体激活中产生，具有促炎潜能，因此可能发挥重要作用。我们测量了 NMO（n=15）、多发性硬化症（MS）（n=15）和其他神经疾病（OND）（n=12）患者的 CSF 和血清中过敏毒素的浓度，并评估了它们的临床意义。NMO 患者的 CSF-C5a 水平显著升高，尤其是在 MRI 上有多个强化病灶的患者中。CSF-C5a 水平与恶化的严重程度相关。我们的结果可能为 NMO 的抗补体治疗提供依据。
