Department of Neurology, The First Affiliated Hospital of Anhui Medical University, Hefei, Anhui Province, China; Department of Neurology, Multiple Sclerosis Center, The Third Affiliated Hospital of Sun-yatsen University, Guangzhou, Guangdong Province, China.
Scand J Immunol. 2014 Feb;79(2):127-30. doi: 10.1111/sji.12132.
Neuromyelitis optica (NMO) and multiple sclerosis (MS) are two of the autoimmune inflammatory demyelinating diseases in the central nervous system. Complement is thought to have an important role in pathogenesis of these diseases, especially in NMO. However, the change of terminal complement complex (TCC, C5b-9) in patients with NMO is still unclear. Cerebrospinal fluid (CSF) C3a, C5a, sC5b-9 were measured by enzyme-linked immunosorbent assay in patients with NMO (n = 26), MS (n = 25) and other neurological disease (OND, n = 19). CSF levels of C5a in patients with NMO were higher than patients with OND (P = 0.006). Increased CSF sC5b-9 were found in the patients with NMO compared with patients with MS (P = 0.029) and OND (P = 0.0001). CSF sC5b-9 in patients with MS were also higher than patients with OND (P = 0.030). Patients with NMO revealed a trend to an increased disease disability with increased CSF sC5b-9 during relapse but not in MS (NMO: P = 0.006, MS: P = 0.097). CSF levels of sC5b-9 are increased in patients with NMO and reflect the activation of complement in NMO.
视神经脊髓炎（NMO）和多发性硬化症（MS）是中枢神经系统自身免疫性炎症脱髓鞘疾病的两种。补体被认为在这些疾病的发病机制中具有重要作用，尤其是在 NMO 中。然而，NMO 患者末端补体复合物（TCC，C5b-9）的变化仍不清楚。通过酶联免疫吸附试验测量了 NMO（n=26）、MS（n=25）和其他神经系统疾病（OND，n=19）患者的脑脊液（CSF）C3a、C5a、sC5b-9。NMO 患者的 CSF C5a 水平高于 OND 患者（P=0.006）。与 MS 患者（P=0.029）和 OND 患者（P=0.0001）相比，NMO 患者的 CSF sC5b-9 升高。MS 患者的 CSF sC5b-9 也高于 OND 患者（P=0.030）。在复发期间，NMO 患者的 CSF sC5b-9 随着疾病残疾程度的增加而增加，但 MS 患者则没有（NMO：P=0.006，MS：P=0.097）。NMO 患者的 CSF sC5b-9 水平升高，反映了 NMO 中补体的激活。
