DNA 损伤：将 BRCA1 置于适当的背景下。
DNA damage: placing BRCA1 in the proper context.
机构信息
Department of Cancer Biology, University of Pennsylvania, 421 Curie Blvd, Philadelphia, PA, USA.
出版信息
Curr Biol. 2012 Sep 25;22(18):R806-8. doi: 10.1016/j.cub.2012.07.046.
Abstract
How does BRCA1's evolutionarily conserved E3 ligase activity contribute to DNA damage responses? Genetically engineered cells containing a BRCA1 RING domain mutation have been used to identify Claspin as a new target of BRCA1 E3 ligase activity in response to specific forms of DNA damage.
摘要
BRCA1 的进化保守的 E3 连接酶活性如何促进 DNA 损伤反应？含有 BRCA1 RING 结构域突变的基因工程细胞被用来鉴定 Claspin 作为 BRCA1 E3 连接酶活性的一个新的靶点，以响应特定形式的 DNA 损伤。
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