中国疾病预防控制中心98号蛋白将乳腺癌1号基因靶向至DNA损伤位点。
CCDC98 targets BRCA1 to DNA damage sites.
作者信息
Liu Zixing, Wu Jiaxue, Yu Xiaochun
机构信息
Division of Molecular Medicine and Genetics, Department of Internal Medicine, University of Michigan Medical School, 109 Zina Pitcher Place, BSRB 1520, Ann Arbor, Michigan 48109, USA.
出版信息
Nat Struct Mol Biol. 2007 Aug;14(8):716-20. doi: 10.1038/nsmb1279. Epub 2007 Jul 22.
Breast cancer-1 (BRCA1) participates in the DNA damage response. However, the mechanism by which BRCA1 is recruited to DNA damage sites remains elusive. Recently, we have demonstrated that a ubiquitin-binding protein, RAP80, is required for DNA damage-induced BRCA1 translocation. Here we identify another component, CCDC98, in the BRCA1-RAP80 complex. CCDC98 mediates BRCA1's association with RAP80. Moreover, CCDC98 controls both DNA damage-induced formation of BRCA1 foci and BRCA1-dependent G2/M checkpoint activation. Together, our results demonstrate that CCDC98 is a BRCA1 binding partner that mediates BRCA1 function in response to DNA damage.
乳腺癌1号基因（BRCA1）参与DNA损伤反应。然而，BRCA1被招募到DNA损伤位点的机制仍不清楚。最近，我们已经证明，一种泛素结合蛋白RAP80是DNA损伤诱导的BRCA1易位所必需的。在这里，我们在BRCA1-RAP80复合物中鉴定出另一个组分CCDC98。CCDC98介导BRCA1与RAP80的结合。此外，CCDC98既控制DNA损伤诱导的BRCA1灶形成，也控制BRCA1依赖的G2/M期检验点激活。总之，我们的结果表明CCDC98是一种BRCA1结合伴侣，其介导BRCA1在响应DNA损伤时的功能。
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