Chowdary R P, Little B W
Department of Plastic and Reconstructive Surgery, Allentown Hospital, Lehigh Valley Hospital Center, PA.
Ann Plast Surg. 1990 Jan;24(1):75-9. doi: 10.1097/00000637-199001000-00014.
Diffuse neurofibroma (paraneurofibroma) is an unusual variant of neurofibroma in which the tumor cells diffusely infiltrate beyond the usual well-circumscribed boundary. Histological features of the tumor include both typical and plexiform neurofibroma. Although benign, diffuse vascularity with the possibility of life-threatening hemorrhage dictates treatment. The combination of preoperative angiography, wide surgical excision, and resurfacing the defect with well-vascularized tissue offers one-stage reconstruction and possible cure.
弥漫性神经纤维瘤（副神经纤维瘤）是神经纤维瘤的一种罕见变体，其中肿瘤细胞弥漫性浸润超出通常界限清楚的边界。该肿瘤的组织学特征包括典型和丛状神经纤维瘤。尽管为良性，但弥漫性血管化伴发危及生命的出血可能性决定了治疗方式。术前血管造影、广泛手术切除以及用血管丰富的组织修复缺损相结合，可提供一期重建并有可能治愈。
