Pirson F, Geubel A, Marot L
Chest Unit, Department of Internal Medicine, Cliniques Universitaires Saint-Luc, Brussels, Belgium.
Acta Clin Belg. 2012 Jul-Aug;67(4):301-3. doi: 10.2143/ACB.67.4.2062678.
A 63 year-old woman presented with a persistent, red, papular, itching skin eruption localised on the face, right shoulder and the right upper member. The evolution was longer than ten years with a permanent progressive diffuse facial burning sensation and unaesthetic aspect despite topical antibiotic and anti-inflammatory treatments. The clinical and the histological diagnosis corresponded to prurigo. She was treated by omeprazole for gastric reflux since more than ten years, and she had a viral C hepatitis. The relationship between prurigo and omeprazole was evidenced by the complete resolution of symptoms after the drug's interruption and the recurrence after the omeprazole re-introduction. The immediate and late skin tests were negative for the tested drugs. Clinical cross-reactivity was observed with pantoprazole and lansoprazole; this suggested a late hypersensitivity to drugs of the proton pump inhibitors class. To our knowledge, it is the first case of prurigo induced by these drugs.
一名63岁女性，面部、右肩部及右上臂出现持续性红色丘疹性瘙痒性皮疹。病程超过十年，尽管接受了局部抗生素和抗炎治疗，但面部仍有持续性进行性弥漫性烧灼感且外观不佳。临床及组织学诊断为痒疹。她因胃食管反流接受奥美拉唑治疗已超过十年，且患有丙型病毒性肝炎。停用奥美拉唑后症状完全缓解，重新使用后复发，从而证实了痒疹与奥美拉唑之间的关系。所检测药物的即刻和迟发性皮肤试验均为阴性。观察到与泮托拉唑和兰索拉唑存在临床交叉反应；这提示对质子泵抑制剂类药物存在迟发性超敏反应。据我们所知，这是首例由这些药物诱发的痒疹病例。
