[双黄连注射液诱导的特异性免疫细胞与类过敏反应的关系]
[Relationship between specific immunocyte and pseudoanaphylactoid reactions induced by Shuanghuanglian injection].
作者信息
Yi Yan, Liang Aihua, Li Chunying, Zhao Yong, Wang Yunting, Li Guiqin
机构信息
Institute of Chinese Materia Medica, China Academy of Chinese Medical Sciences, Beijing 100700, China.
出版信息
Zhongguo Zhong Yao Za Zhi. 2012 Jul;37(13):1898-900.
OBJECTIVE
To investigate the relationship between specific immunocyte and pseudoanaphylactoid reactions (PR) induced by Shuanghuanglian injection (SHLI).
METHOD
ICR mice, SCID mice and BALB/C athymic mouse were divided into different test groups, the mice were intravenously injected with solutions of different concentration of SHLI, positive control Compound 48/80 and normal sodium. All test substances were mixed with 0. 4% Evans blue. The reaction and vascular permeability of the ears were observed and measured 30 min after SHLI injected.
RESULT
SHLI of 300, 600 mg x kg(-1) caused obvious vascular hyperpermeability in ICR mice, but the same dose of SHLI didn't cause vascular hyperpermeability in SCID mice and BALB/C athymic mouse.
CONCLUSION
SHLI in equivalent and 2 times the clinical dose can cause PR in ICR mice, but the same dose of SHLI can't cause PR in SCID mice and BALB/C athymic mouse, so specific immunocyte maybe take part in the SHLI-induced PR.
目的
探讨双黄连注射液（SHLI）诱导的类过敏反应（PR）与特定免疫细胞之间的关系。
方法
将ICR小鼠、SCID小鼠和BALB/C裸鼠分为不同的试验组，给小鼠静脉注射不同浓度的SHLI溶液、阳性对照化合物48/80和生理盐水。所有受试物质均与0.4%伊文思蓝混合。注射SHLI 30分钟后，观察并测量耳部的反应和血管通透性。
结果
300、600mg·kg⁻¹的SHLI可引起ICR小鼠明显的血管通透性增高，但相同剂量的SHLI在SCID小鼠和BALB/C裸鼠中未引起血管通透性增高。
结论
相当于临床剂量及2倍临床剂量的SHLI可在ICR小鼠中引起PR，但相同剂量的SHLI在SCID小鼠和BALB/C裸鼠中不能引起PR，因此特定免疫细胞可能参与了SHLI诱导的PR。
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