Yin Jie, Wang Shao-Yu, Song Yan-Feng, Jing Yu-Hong
Institute of human Anatomy and Histology and Embryology, School of Basic Medical Science, Lanzhou University, Lanzhou 730000, China.
Sheng Li Ke Xue Jin Zhan. 2012 Jun;43(3):183-7.
Gap junction is a direct communication between the cells as the channel, which exists widely in the central nervous system involving in transporting the electronic and chemical messages between neurons and glias. It plays roles in regulation of metabolism, ion buffer, "calcium wave" as well ATP receptor signal. Gap junction also has been complicated in the nerve growth and development. Switching the gap junction participates in pathological process and maintainning the local metabolites concentration. Calcium wave is the prominently regulated by gap junction. In the central nervous system, it is remain to be elucidated whether the gap junction play roles in embryonic development and pathophysiological processes.
缝隙连接是细胞间通过通道进行的直接通讯，广泛存在于中枢神经系统中，参与神经元与神经胶质细胞之间电信号和化学信号的传递。它在代谢调节、离子缓冲、“钙波”以及ATP受体信号传导中发挥作用。缝隙连接在神经生长和发育过程中也具有复杂的作用。缝隙连接的开关参与病理过程并维持局部代谢物浓度。钙波受缝隙连接的显著调节。在中枢神经系统中，缝隙连接在胚胎发育和病理生理过程中是否发挥作用仍有待阐明。
