Departments of Dermatology Pathology, University Hospital Spedali Civili, Brescia, Italy.
Clin Exp Dermatol. 2012 Dec;37(8):857-61. doi: 10.1111/j.1365-2230.2012.04455.x. Epub 2012 Oct 1.
The risk of a subsequent cancer is an important issue for patients with melanoma. The development of a second primary cancer in patients with a solitary melanoma has been discussed in several studies. However, to our knowledge, the incidence of second primary cancer (SPC) in patients with multiple primary melanoma (MPM) has not been thoroughly investigated.
To quantify the incidence of SPC in patients with MPM, with the aim of possibly developing further preventive measures.
In a retrospective study, 76 patients with MPM were identified from 2155 patients being followed up at our unit.
Of the 76 patients, 12 (16%) developed another neoplasm, with 59% of them having nonmelanoma skin cancer (NMSC), and 41% other noncutaneous cancers. By contrast, only 8% of those with single primary melanoma had other neoplasms (21% of whom had NMSC).
Patients with MPM, especially men with skin phototype II, have a significantly increased incidence of developing SPC, particularly NMSC. Thus, careful monitoring is essential not only to detect recurrence of the original cancer or development of another primary melanoma, but also development of new malignancies of different types, particularly NMSC.
对于黑色素瘤患者来说，继发癌症的风险是一个重要问题。已有多项研究探讨了单发黑色素瘤患者发生第二原发癌的风险。然而，据我们所知，多发性黑色素瘤（MPM）患者的第二原发癌（SPC）发生率尚未得到充分研究。
定量评估 MPM 患者发生 SPC 的概率，以期可能制定出进一步的预防措施。
我们进行了一项回顾性研究，从在本单位接受随访的 2155 例患者中确定了 76 例 MPM 患者。
在这 76 例患者中，有 12 例（16%）发生了另一种肿瘤，其中 59%为非黑色素瘤皮肤癌（NMSC），41%为其他非皮肤癌。相比之下，单发黑色素瘤患者中仅有 8%发生了其他肿瘤（其中 21%为 NMSC）。
MPM 患者，尤其是皮肤光型 II 的男性，发生 SPC 的风险显著增加，尤其是 NMSC。因此，不仅需要仔细监测以发现原始癌症的复发或另一种原发性黑色素瘤的发生，还需要监测不同类型的新发恶性肿瘤，尤其是 NMSC。
