Department of Human Movement Science, Norwegian University of Science and Technology, Trondheim, Norway.
Occup Environ Med. 2013 Feb;70(2):86-90. doi: 10.1136/oemed-2012-100734. Epub 2012 Sep 28.
To prospectively examine the independent and combined effect of occupational physical activity and metabolic syndrome on all-cause and cardiovascular mortality in a large population-based cohort.
Data on 37 300 men and women participating in the Norwegian HUNT Study (1995-1997) were linked with the Cause of Death Registry at Statistics Norway. Cox proportional HR with 95% CI were estimated.
During a median follow-up of 12.4 years, a total of 1168 persons died. Of these, 278 died from cardiovascular disease. Persons with metabolic syndrome and much walking/lifting at work had a HR of 1.79 (95% CI 1.20 to 2.66) for cardiovascular death referencing persons without metabolic syndrome and much walking/lifting. Using the same reference, persons with metabolic syndrome and sedentary work had a HR of 2.74 (95% CI 1.82 to 4.12) while persons with metabolic syndrome and heavy physical work had a HR of 3.02 (95% CI 1.93 to 4.75). Associations with all-cause mortality were somewhat weaker, and were largely due to deaths from cardiovascular disease.
The association between metabolic syndrome and cardiovascular mortality is stronger for persons with sedentary work and with physically heavy work than for persons with much walking/lifting at work.
前瞻性研究职业体力活动和代谢综合征对大型基于人群队列的全因和心血管死亡率的独立和联合影响。
将参加挪威亨于特研究（1995-1997 年）的 37300 名男性和女性的数据与挪威统计局的死因登记处进行了关联。使用 Cox 比例风险 HR 及其 95%CI 进行了估计。
在中位随访 12.4 年期间，共有 1168 人死亡。其中，278 人死于心血管疾病。与没有代谢综合征和大量步行/举重的人相比，患有代谢综合征和大量工作中需要走动/举重的人发生心血管死亡的 HR 为 1.79（95%CI 1.20 至 2.66）。以同样的参考标准，患有代谢综合征和久坐工作的人发生心血管死亡的 HR 为 2.74（95%CI 1.82 至 4.12），而患有代谢综合征和体力劳动繁重的人发生心血管死亡的 HR 为 3.02（95%CI 1.93 至 4.75）。与全因死亡率的相关性稍弱，主要归因于心血管疾病导致的死亡。
代谢综合征与心血管死亡率之间的关联对于久坐工作和体力劳动繁重的人比需要大量走动/举重的人更强。
