Prevention Research Collaboration, Sydney School of Public Health, University of Sydney, Sydney, Australia.
HUNT Research Centre, Department of Public Health and General Practice, Faculty of Medicine, Norwegian University of Science and Technology, Levanger, Norway.
Br J Sports Med. 2015 Jun;49(11):737-42. doi: 10.1136/bjsports-2012-091974. Epub 2013 May 10.
Sedentary behaviour is a potential risk factor for chronic-ill health and mortality, that is, independent of health-enhancing physical activity. Few studies have investigated the risk of mortality associated with multiple contexts of sedentary behaviour.
To examine the prospective associations of total sitting time, TV-viewing time and occupational sitting with mortality from all causes and cardiometabolic diseases.
Data from 50,817 adults aged ≥20 years from the Nord-Trøndelag Health Study 3 (HUNT3) in 2006-2008 were linked to the Norwegian Cause of Death Registry up to 31 December 2010. Cox proportional hazards models examined all-cause and cardiometabolic disease-related mortality associated with total sitting time, TV-viewing and occupational sitting, adjusting for multiple potential confounders including physical activity.
After mean follow-up of 3.3 years (137,315.8 person-years), 1068 deaths were recorded of which 388 were related to cardiometabolic diseases. HRs for all-cause mortality associated with total sitting time were 1.12 (95% CI 0.89 to 1.42), 1.18 (95% CI 0.90 to 1.57) and 1.65 (95% CI 1.24 to 2.21) for total sitting time 4-<7, 7-<10 and ≥10 h/day, respectively, relative to <4 h/day after adjusting for confounders (p-trend=0.001). A similar pattern of associations was observed between total sitting time and mortality from cardiometabolic diseases, but TV-viewing time and occupational sitting showed no or borderline significant associations with all-cause or cardiometabolic disease-related mortality over the same follow-up period.
Total sitting time is associated with all-cause and cardiometabolic disease-related mortality in the short term. However, prolonged sitting in specific contexts (ie, watching TV, at work) do not adversely impact health in the same timeframe. These findings suggest that adults should be encouraged to sit less throughout the day to reduce their daily total sitting time.
久坐行为是导致慢性疾病和死亡的潜在风险因素，即与促进健康的体力活动无关。很少有研究调查与多种久坐行为背景相关的死亡风险。
研究总坐姿时间、看电视时间和职业坐姿与全因和心血管疾病死亡率的前瞻性关联。
2006-2008 年，来自挪威诺德兰特伦德拉格健康研究 3 期（HUNT3）的 50817 名年龄≥20 岁的成年人的数据与挪威死因登记处进行了链接，直至 2010 年 12 月 31 日。Cox 比例风险模型检验了总坐姿时间、看电视和职业坐姿与全因和心血管疾病相关死亡率的关联，调整了包括体力活动在内的多种潜在混杂因素。
平均随访 3.3 年后（137315.8 人年），记录了 1068 例死亡，其中 388 例与心血管疾病有关。与总坐姿时间<4 小时/天相比，总坐姿时间为 4-<7、7-<10 和≥10 小时/天的全因死亡率 HR 分别为 1.12（95%CI 0.89 至 1.42）、1.18（95%CI 0.90 至 1.57）和 1.65（95%CI 1.24 至 2.21），在调整混杂因素后（趋势 P=0.001）。在同样的随访期间，总坐姿时间与心血管疾病死亡率之间也存在类似的关联模式，但看电视时间和职业坐姿与全因或心血管疾病相关死亡率之间没有关联或关联仅具有边缘统计学意义。
总坐姿时间与短期全因和心血管疾病相关死亡率相关。然而，在特定环境（即看电视、工作）中长时间久坐不会在同一时间段内对健康产生不利影响。这些发现表明，应鼓励成年人全天减少坐姿时间，以降低每天的总坐姿时间。
