Gianos M E, Klaustermeyer W B, Kurohara M, Tarnasky P, Gordon E
Allergy and Immunology Section, Wadsworth VA Medical Center, Los Angeles, CA 90073.
Am J Emerg Med. 1990 Mar;8(2):124-6. doi: 10.1016/0735-6757(90)90198-9.
A report of three patients who developed angiodema while receiving enalapril. Patient 1 came in with an 8-hour history of facial swelling after enalapril had been started 2 days earlier. The second patient came in with severe angiodema of the tongue, larynx, and glottis requiring emergency tracheostomy, hydroxyzine, and steroids. He had been treated with enalapril for 1 year. The third patient developed facial swelling within a few hours of the first dose of enalapril. Angiodema with enalapril can occur early or late in the course of therapy. A possible mechanism for this drug reaction is the potentiation of bradykinin with resultant kinin system activation.
三例接受依那普利治疗时发生血管性水肿患者的报告。患者1在开始使用依那普利2天后出现面部肿胀，病史为8小时。第二名患者因舌、喉和声门严重血管性水肿前来就诊，需要紧急气管切开术、羟嗪和类固醇治疗。他接受依那普利治疗已1年。第三名患者在首次服用依那普利后数小时内出现面部肿胀。依那普利引起的血管性水肿可在治疗过程的早期或晚期出现。这种药物反应的一种可能机制是缓激肽增强，导致激肽系统激活。
