N-杂环卡宾催化氯代醛和 1-偶氮二烯的高对映选择性[4 + 2]环化反应。

Highly enantioselective [4 + 2] cyclization of chloroaldehydes and 1-azadienes catalyzed by N-heterocyclic carbenes.

机构信息

Beijing National Laboratory for Molecular Sciences, Institute of Chemistry, Chinese Academy of Sciences, Beijing 100190, China.

出版信息

Chem Commun (Camb). 2012 Nov 14;48(88):10907-9. doi: 10.1039/c2cc35273g.

DOI:10.1039/c2cc35273g

PMID:23023792

Abstract

Highly functionalized dihydropyridinones were synthesized via the N-heterocyclic carbene-catalyzed enantioselective [4 + 2] annulation of α-chloroaldehydes and azadienes. Hydrogenation of the resulted dihydropyridinones afforded the corresponding piperidinones with high enantiopurity.

摘要

高官能化的二氢吡啶酮通过 N-杂环卡宾催化的α-氯醛和氮杂二烯的对映选择性[4+2]环加成反应合成。所得二氢吡啶酮经氢化得到相应的高对映纯度的哌啶酮。